Silver nanoparticle - Oligonucleotide conjugates based on DNA with triple cyclic disulfide moieties

Jae-Seung Lee, Abigail K R Lytton-Jean, Sarah J. Hurst, Chad A. Mirkin

Research output: Contribution to journalArticle

342 Citations (Scopus)

Abstract

We report a new strategy for preparing silver nanoparticle-oligonucleotide conjugates that are based upon DNA with cyclic disulfide-anchoring groups. These particles are extremely stable and can withstand NaCI concentrations up to 1.0 M. When silver nanoparticles functionalized with complementary sequences are combined, they assemble to form DNA-linked nanoparticle networks. This assembly process is reversible with heating and is associated with a red shifting of the particle surface plasmon resonance and a concomitant color change from yellow to pale red. Analogous to the oligonucleotide-functionalized gold nanoparticles, these particles also exhibit highly cooperative binding properties with extremely sharp melting transitions. This work is an important step toward using silver nanoparticle-oligonucleotide conjugates for a variety of purposes, including molecular diagnostic labels, synthons in programmable materials synthesis approaches, and functional components for nanoelectronic and plasmonic devices.

Original languageEnglish
Pages (from-to)2112-2115
Number of pages4
JournalNano Letters
Volume7
Issue number7
DOIs
Publication statusPublished - 2007 Jul 1
Externally publishedYes

Fingerprint

oligonucleotides
Oligonucleotides
disulfides
Silver
Disulfides
DNA
deoxyribonucleic acid
silver
Nanoparticles
nanoparticles
Nanoelectronics
Surface plasmon resonance
surface plasmon resonance
Gold
Labels
Melting
assembly
melting
gold
Color

ASJC Scopus subject areas

  • Materials Science(all)
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)

Cite this

Silver nanoparticle - Oligonucleotide conjugates based on DNA with triple cyclic disulfide moieties. / Lee, Jae-Seung; Lytton-Jean, Abigail K R; Hurst, Sarah J.; Mirkin, Chad A.

In: Nano Letters, Vol. 7, No. 7, 01.07.2007, p. 2112-2115.

Research output: Contribution to journalArticle

Lee, Jae-Seung ; Lytton-Jean, Abigail K R ; Hurst, Sarah J. ; Mirkin, Chad A. / Silver nanoparticle - Oligonucleotide conjugates based on DNA with triple cyclic disulfide moieties. In: Nano Letters. 2007 ; Vol. 7, No. 7. pp. 2112-2115.
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