Simple measurement of spinal cord evoked potential: A valuable data source in the rat spinal cord injury model

Jong Pil Park, Ki Jeong Kim, Ji Hoon Phi, Chul Kee Park, Jong Hoon Kim, Hyo Jin Kang, Dohun Lee, Kyu Hyun Han, Kyu Chang Wang, Sun Ha Paek

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Measurement of spinal cord evoked potentials (SCEPs) is proposed as a means of predicting locomotion outcome in the rat spinal cord injury (SCI) model. Using 55 rats, three reproducible peak waves (waves I, II and III) were observed during stimulation at the C7 level with recording at the L1 epidural space. Hemisection at the T13 level showed three wave loss patterns: wave III loss only, loss of both wave II and III, and loss of all three waves. Defining an ideal SCI model as establishment of stable monoparesis or paraparesis, all animals in the wave II-III loss group showed favorable results. Histological data and electrophysiological properties allowed reasonable assumptions of wave origin: wave I from extrapyramidal tracts, wave II from the ventral corticospinal tract, and wave III from the dorsal corticospinal tract. Complete destruction of pyramidal tracts in both dorsal and ventral fibers was essential for long-term impairment of locomotion.

Original languageEnglish
Pages (from-to)1099-1105
Number of pages7
JournalJournal of Clinical Neuroscience
Volume14
Issue number11
DOIs
Publication statusPublished - 2007 Nov

Keywords

  • Corticospinal tract
  • Hemisection
  • Locomotion
  • Rat spinal cord injury model
  • Spinal cord evoked potential

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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