Abstract
In this study, we found a simple surface biofunctionalization of biphasic calcium phosphate (BCP) based on the high affinity between alendronate and the calcium ions of BCP, and the strong interaction between heparin and bone morphogenic protein-2 (BMP-2). The biofunctionalized BCP did not be precipitated well and display a remarkable enhancement of osteogenic activity of human adipose-derived stem cells by showing increased alkaline phosphatase (ALP), calcium deposition and osteogenic-related genes (i.e., Runx-2, ALP, osteocalcin, and osteopontin), and bone regeneration in the calvarial defect model. Therefore, this simple surface technique can be used to easily functionalize various calcium phosphates.
| Original language | English |
|---|---|
| Journal | Journal of Industrial and Engineering Chemistry |
| DOIs | |
| Publication status | Accepted/In press - 2018 Jan 1 |
Keywords
- Alendronate
- Biphasic calcium phosphate
- Heparin
- Osteogenesis
- Surface biofunctionalization
ASJC Scopus subject areas
- Chemical Engineering(all)
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Cite this
Shim, K. S., Kim, H. J., Kim, S. E., & Park, K. (Accepted/In press). Simple surface biofunctionalization of biphasic calcium phosphates for improving osteogenic activity and bone tissue regeneration. Journal of Industrial and Engineering Chemistry. https://doi.org/10.1016/j.jiec.2018.07.048