Simple surface biofunctionalization of biphasic calcium phosphates for improving osteogenic activity and bone tissue regeneration

Kyu Sik Shim, Hak Jun Kim, Sung Eum Kim, Kyeongsoon Park

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In this study, we found a simple surface biofunctionalization of biphasic calcium phosphate (BCP) based on the high affinity between alendronate and the calcium ions of BCP, and the strong interaction between heparin and bone morphogenic protein-2 (BMP-2). The biofunctionalized BCP did not be precipitated well and display a remarkable enhancement of osteogenic activity of human adipose-derived stem cells by showing increased alkaline phosphatase (ALP), calcium deposition and osteogenic-related genes (i.e., Runx-2, ALP, osteocalcin, and osteopontin), and bone regeneration in the calvarial defect model. Therefore, this simple surface technique can be used to easily functionalize various calcium phosphates.

Original languageEnglish
JournalJournal of Industrial and Engineering Chemistry
DOIs
Publication statusAccepted/In press - 2018 Jan 1

Keywords

  • Alendronate
  • Biphasic calcium phosphate
  • Heparin
  • Osteogenesis
  • Surface biofunctionalization

ASJC Scopus subject areas

  • Chemical Engineering(all)

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