Simple surface biofunctionalization of biphasic calcium phosphates for improving osteogenic activity and bone tissue regeneration

Kyu Sik Shim, Hak Jun Kim, Sung Eum Kim, Kyeongsoon Park

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    In this study, we found a simple surface biofunctionalization of biphasic calcium phosphate (BCP) based on the high affinity between alendronate and the calcium ions of BCP, and the strong interaction between heparin and bone morphogenic protein-2 (BMP-2). The biofunctionalized BCP did not be precipitated well and display a remarkable enhancement of osteogenic activity of human adipose-derived stem cells by showing increased alkaline phosphatase (ALP), calcium deposition and osteogenic-related genes (i.e., Runx-2, ALP, osteocalcin, and osteopontin), and bone regeneration in the calvarial defect model. Therefore, this simple surface technique can be used to easily functionalize various calcium phosphates.

    Original languageEnglish
    Pages (from-to)220-228
    Number of pages9
    JournalJournal of Industrial and Engineering Chemistry
    Volume68
    DOIs
    Publication statusPublished - 2018 Dec 25

    Keywords

    • Alendronate
    • Biphasic calcium phosphate
    • Heparin
    • Osteogenesis
    • Surface biofunctionalization

    ASJC Scopus subject areas

    • Chemical Engineering(all)

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