Abstract
In this study, we found a simple surface biofunctionalization of biphasic calcium phosphate (BCP) based on the high affinity between alendronate and the calcium ions of BCP, and the strong interaction between heparin and bone morphogenic protein-2 (BMP-2). The biofunctionalized BCP did not be precipitated well and display a remarkable enhancement of osteogenic activity of human adipose-derived stem cells by showing increased alkaline phosphatase (ALP), calcium deposition and osteogenic-related genes (i.e., Runx-2, ALP, osteocalcin, and osteopontin), and bone regeneration in the calvarial defect model. Therefore, this simple surface technique can be used to easily functionalize various calcium phosphates.
| Original language | English |
|---|---|
| Journal | Journal of Industrial and Engineering Chemistry |
| DOIs | |
| Publication status | Accepted/In press - 2018 Jan 1 |
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Keywords
- Alendronate
- Biphasic calcium phosphate
- Heparin
- Osteogenesis
- Surface biofunctionalization
ASJC Scopus subject areas
- Chemical Engineering(all)
Cite this
Simple surface biofunctionalization of biphasic calcium phosphates for improving osteogenic activity and bone tissue regeneration. / Shim, Kyu Sik; Kim, Hak Jun; Kim, Sung Eum; Park, Kyeongsoon.
In: Journal of Industrial and Engineering Chemistry, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Simple surface biofunctionalization of biphasic calcium phosphates for improving osteogenic activity and bone tissue regeneration
AU - Shim, Kyu Sik
AU - Kim, Hak Jun
AU - Kim, Sung Eum
AU - Park, Kyeongsoon
PY - 2018/1/1
Y1 - 2018/1/1
N2 - In this study, we found a simple surface biofunctionalization of biphasic calcium phosphate (BCP) based on the high affinity between alendronate and the calcium ions of BCP, and the strong interaction between heparin and bone morphogenic protein-2 (BMP-2). The biofunctionalized BCP did not be precipitated well and display a remarkable enhancement of osteogenic activity of human adipose-derived stem cells by showing increased alkaline phosphatase (ALP), calcium deposition and osteogenic-related genes (i.e., Runx-2, ALP, osteocalcin, and osteopontin), and bone regeneration in the calvarial defect model. Therefore, this simple surface technique can be used to easily functionalize various calcium phosphates.
AB - In this study, we found a simple surface biofunctionalization of biphasic calcium phosphate (BCP) based on the high affinity between alendronate and the calcium ions of BCP, and the strong interaction between heparin and bone morphogenic protein-2 (BMP-2). The biofunctionalized BCP did not be precipitated well and display a remarkable enhancement of osteogenic activity of human adipose-derived stem cells by showing increased alkaline phosphatase (ALP), calcium deposition and osteogenic-related genes (i.e., Runx-2, ALP, osteocalcin, and osteopontin), and bone regeneration in the calvarial defect model. Therefore, this simple surface technique can be used to easily functionalize various calcium phosphates.
KW - Alendronate
KW - Biphasic calcium phosphate
KW - Heparin
KW - Osteogenesis
KW - Surface biofunctionalization
UR - http://www.scopus.com/inward/record.url?scp=85051048125&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051048125&partnerID=8YFLogxK
U2 - 10.1016/j.jiec.2018.07.048
DO - 10.1016/j.jiec.2018.07.048
M3 - Article
AN - SCOPUS:85051048125
JO - Journal of Industrial and Engineering Chemistry
JF - Journal of Industrial and Engineering Chemistry
SN - 1226-086X
ER -