TY - JOUR
T1 - Simple surface biofunctionalization of biphasic calcium phosphates for improving osteogenic activity and bone tissue regeneration
AU - Shim, Kyu Sik
AU - Kim, Hak Jun
AU - Kim, Sung Eum
AU - Park, Kyeongsoon
N1 - Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the NRF funded by the Korean government, MSIP (NRF-2017M3A9B3063640) and by the Chung-Ang University Research Grants in 2017.
Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the NRF funded by the Korean government , MSIP (NRF- 2017M3A9B3063640 ) and by the Chung-Ang University Research Grants in 2017.
PY - 2018/12/25
Y1 - 2018/12/25
N2 - In this study, we found a simple surface biofunctionalization of biphasic calcium phosphate (BCP) based on the high affinity between alendronate and the calcium ions of BCP, and the strong interaction between heparin and bone morphogenic protein-2 (BMP-2). The biofunctionalized BCP did not be precipitated well and display a remarkable enhancement of osteogenic activity of human adipose-derived stem cells by showing increased alkaline phosphatase (ALP), calcium deposition and osteogenic-related genes (i.e., Runx-2, ALP, osteocalcin, and osteopontin), and bone regeneration in the calvarial defect model. Therefore, this simple surface technique can be used to easily functionalize various calcium phosphates.
AB - In this study, we found a simple surface biofunctionalization of biphasic calcium phosphate (BCP) based on the high affinity between alendronate and the calcium ions of BCP, and the strong interaction between heparin and bone morphogenic protein-2 (BMP-2). The biofunctionalized BCP did not be precipitated well and display a remarkable enhancement of osteogenic activity of human adipose-derived stem cells by showing increased alkaline phosphatase (ALP), calcium deposition and osteogenic-related genes (i.e., Runx-2, ALP, osteocalcin, and osteopontin), and bone regeneration in the calvarial defect model. Therefore, this simple surface technique can be used to easily functionalize various calcium phosphates.
KW - Alendronate
KW - Biphasic calcium phosphate
KW - Heparin
KW - Osteogenesis
KW - Surface biofunctionalization
UR - http://www.scopus.com/inward/record.url?scp=85051048125&partnerID=8YFLogxK
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U2 - 10.1016/j.jiec.2018.07.048
DO - 10.1016/j.jiec.2018.07.048
M3 - Article
AN - SCOPUS:85051048125
VL - 68
SP - 220
EP - 228
JO - Journal of Industrial and Engineering Chemistry
JF - Journal of Industrial and Engineering Chemistry
SN - 1226-086X
ER -