Abstract
Monte Carlo simulations were performed for a three-dimensional tissue model with and without an embedded large vessel, to understand how varying vessel geometry affects surface light distribution. Vessel radius was varied from 1 to 5 mm, and vessel depth from 2 to 10 mm. A larger difference in surface fluence rate was observed when the vessel’s radius increased. For vessel depth, the largest difference was seen at a depth of approximately 4 mm, corresponding to human wrist region. When the vessel was placed at depths greater than 8 mm, very little difference was observed. We also tested the feasibility of using two source-detector pairs, comprising two detectors distinctly spaced from a common source, to noninvasively measure blood-scattering changes in a large vessel. High sensitivity to blood-scattering changes was achieved by placing the near detector closer to the source and moving the far detector away from the source. However, at longer distances, increasing noise levels limited the sensitivity of the two-detector approach. Our results indicate that the approach using two source-detector pairs may have potential for quantitative measurement of scattering changes in the blood while targeting large vessels near the human wrist region.
| Original language | English |
|---|---|
| Pages (from-to) | 46-53 |
| Number of pages | 8 |
| Journal | Current Optics and Photonics |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
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Keywords
- Blood vessel
- Monte Carlo
- Scattering
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
Cite this
Simulation studies for noninvasive optical measurements of blood-scattering changes in a skin model with a large blood vessel. / Zephaniah Phillips, V.; Paik, Seung Ho; Nam, Jungyong; Chang, Ki Young; Jung, Young Jin; Choi, Youngwoon; Lee, Joonhyung; Kim, Beop-Min.
In: Current Optics and Photonics, Vol. 3, No. 1, 01.01.2019, p. 46-53.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Simulation studies for noninvasive optical measurements of blood-scattering changes in a skin model with a large blood vessel
AU - Zephaniah Phillips, V.
AU - Paik, Seung Ho
AU - Nam, Jungyong
AU - Chang, Ki Young
AU - Jung, Young Jin
AU - Choi, Youngwoon
AU - Lee, Joonhyung
AU - Kim, Beop-Min
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Monte Carlo simulations were performed for a three-dimensional tissue model with and without an embedded large vessel, to understand how varying vessel geometry affects surface light distribution. Vessel radius was varied from 1 to 5 mm, and vessel depth from 2 to 10 mm. A larger difference in surface fluence rate was observed when the vessel’s radius increased. For vessel depth, the largest difference was seen at a depth of approximately 4 mm, corresponding to human wrist region. When the vessel was placed at depths greater than 8 mm, very little difference was observed. We also tested the feasibility of using two source-detector pairs, comprising two detectors distinctly spaced from a common source, to noninvasively measure blood-scattering changes in a large vessel. High sensitivity to blood-scattering changes was achieved by placing the near detector closer to the source and moving the far detector away from the source. However, at longer distances, increasing noise levels limited the sensitivity of the two-detector approach. Our results indicate that the approach using two source-detector pairs may have potential for quantitative measurement of scattering changes in the blood while targeting large vessels near the human wrist region.
AB - Monte Carlo simulations were performed for a three-dimensional tissue model with and without an embedded large vessel, to understand how varying vessel geometry affects surface light distribution. Vessel radius was varied from 1 to 5 mm, and vessel depth from 2 to 10 mm. A larger difference in surface fluence rate was observed when the vessel’s radius increased. For vessel depth, the largest difference was seen at a depth of approximately 4 mm, corresponding to human wrist region. When the vessel was placed at depths greater than 8 mm, very little difference was observed. We also tested the feasibility of using two source-detector pairs, comprising two detectors distinctly spaced from a common source, to noninvasively measure blood-scattering changes in a large vessel. High sensitivity to blood-scattering changes was achieved by placing the near detector closer to the source and moving the far detector away from the source. However, at longer distances, increasing noise levels limited the sensitivity of the two-detector approach. Our results indicate that the approach using two source-detector pairs may have potential for quantitative measurement of scattering changes in the blood while targeting large vessels near the human wrist region.
KW - Blood vessel
KW - Monte Carlo
KW - Scattering
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UR - http://www.scopus.com/inward/citedby.url?scp=85069481218&partnerID=8YFLogxK
U2 - 10.3807/COPP.2019.3.1.046
DO - 10.3807/COPP.2019.3.1.046
M3 - Article
AN - SCOPUS:85069481218
VL - 3
SP - 46
EP - 53
JO - Current Optics and Photonics
JF - Current Optics and Photonics
SN - 2508-7266
IS - 1
ER -