Simulation study of dose enhancement in a cell due to nearby carbon and oxygen in particle radiotherapy

Jae Ik Shin, Ilsung Cho, Sungho Cho, Eun Ho Kim, Yongkeun Song, Won Gyun Jung, Seung Hoon Yoo, Dongho Shin, Se Byeong Lee, Myonggeun Yoon, S´ebastian Incerti, Moshi Geso, Anatoly B. Rosenfeld

Research output: Contribution to journalArticle

Abstract

The aim of this study is to investigate the dose-deposition enhancement due to alpha-particle irradiation in a cellular model by using the carbon and the oxygen chemical compositions. A simulation study was performed to study dose enhancement due to carbon and oxygen for a human cell where the Geant4 code used for alpha-particle irradiation of a cellular phantom. The characteristics of the dose enhancements based on the concentrations of carbon and oxygen in the nucleus and cytoplasm by the alpha-particle radiation was investigated and was compared with those obtained by gold and gadolinium. The results showed that both the carbon- and the oxygen-induced dose enhancements were more effective than those of gold and gadolinium. We found that the dose enhancement effect was more dominant in the nucleus than in the cytoplasm if the carbon or the oxygen were uniformly distributed in the whole cell. For the condition that the added chemical composition was inserted only into the cytoplasm, the effect of the dose enhancement in the nucleus was weak. We showed that high-stopping-power materials offer a more effective dose enhancement efficacy and suggest that carbon nanotubes and oxygenation are promising candidates for dose enhancement tools in particle therapy.

Original languageEnglish
Pages (from-to)209-217
Number of pages9
JournalJournal of the Korean Physical Society
Volume67
Issue number1
DOIs
Publication statusPublished - 2015 Jul 31

Fingerprint

radiation therapy
dosage
augmentation
carbon
oxygen
cells
cytoplasm
simulation
alpha particles
gadolinium
nuclei
chemical composition
gold
irradiation
oxygenation
stopping power
therapy
carbon nanotubes
radiation

Keywords

  • Alpha particle
  • CNT
  • Dose enhancement
  • Nanoparticle

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Simulation study of dose enhancement in a cell due to nearby carbon and oxygen in particle radiotherapy. / Shin, Jae Ik; Cho, Ilsung; Cho, Sungho; Kim, Eun Ho; Song, Yongkeun; Jung, Won Gyun; Yoo, Seung Hoon; Shin, Dongho; Lee, Se Byeong; Yoon, Myonggeun; Incerti, S´ebastian; Geso, Moshi; Rosenfeld, Anatoly B.

In: Journal of the Korean Physical Society, Vol. 67, No. 1, 31.07.2015, p. 209-217.

Research output: Contribution to journalArticle

Shin, JI, Cho, I, Cho, S, Kim, EH, Song, Y, Jung, WG, Yoo, SH, Shin, D, Lee, SB, Yoon, M, Incerti, S, Geso, M & Rosenfeld, AB 2015, 'Simulation study of dose enhancement in a cell due to nearby carbon and oxygen in particle radiotherapy', Journal of the Korean Physical Society, vol. 67, no. 1, pp. 209-217. https://doi.org/10.3938/jkps.67.209
Shin, Jae Ik ; Cho, Ilsung ; Cho, Sungho ; Kim, Eun Ho ; Song, Yongkeun ; Jung, Won Gyun ; Yoo, Seung Hoon ; Shin, Dongho ; Lee, Se Byeong ; Yoon, Myonggeun ; Incerti, S´ebastian ; Geso, Moshi ; Rosenfeld, Anatoly B. / Simulation study of dose enhancement in a cell due to nearby carbon and oxygen in particle radiotherapy. In: Journal of the Korean Physical Society. 2015 ; Vol. 67, No. 1. pp. 209-217.
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