Simultaneous generation of chemical concentration and mechanical shear stress gradients in a microfluidic chip

Sung Ju Yoo, Joong Yull Park, Chang Mo Hwang, Gi Seok Jeong, Sang Hoon Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We describe a simple and versatile method to study the generation of chemical concentration and mechanical shear stress gradients in a single microfluidic chip. Our system uses an osmotic pump that generates very slow and controlled flow [1]. For evaluation of the system, we used L929 mouse fibroblast cells and exposed them to a mechanical stress gradient and a chemical nutrient gradient at once.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages147-149
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - 2009 Jan 1
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: 2009 Nov 12009 Nov 5

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
CountryKorea, Republic of
CityJeju
Period09/11/109/11/5

Fingerprint

Fibroblasts
Microfluidics
Nutrients
Shear stress
Cells
Pumps

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Yoo, S. J., Park, J. Y., Hwang, C. M., Jeong, G. S., & Lee, S. H. (2009). Simultaneous generation of chemical concentration and mechanical shear stress gradients in a microfluidic chip. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 147-149). Chemical and Biological Microsystems Society.

Simultaneous generation of chemical concentration and mechanical shear stress gradients in a microfluidic chip. / Yoo, Sung Ju; Park, Joong Yull; Hwang, Chang Mo; Jeong, Gi Seok; Lee, Sang Hoon.

Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2009. p. 147-149.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yoo, SJ, Park, JY, Hwang, CM, Jeong, GS & Lee, SH 2009, Simultaneous generation of chemical concentration and mechanical shear stress gradients in a microfluidic chip. in Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, pp. 147-149, 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009, Jeju, Korea, Republic of, 09/11/1.
Yoo SJ, Park JY, Hwang CM, Jeong GS, Lee SH. Simultaneous generation of chemical concentration and mechanical shear stress gradients in a microfluidic chip. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society. 2009. p. 147-149
Yoo, Sung Ju ; Park, Joong Yull ; Hwang, Chang Mo ; Jeong, Gi Seok ; Lee, Sang Hoon. / Simultaneous generation of chemical concentration and mechanical shear stress gradients in a microfluidic chip. Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2009. pp. 147-149
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