Simultaneous generation of chemical concentration and mechanical shear stress gradients in a microfluidic chip

Sung Ju Yoo, Joong Yull Park, Chang Mo Hwang, Gi Seok Jeong, Sang Hoon Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We describe a simple and versatile method to study the generation of chemical concentration and mechanical shear stress gradients in a single microfluidic chip. Our system uses an osmotic pump that generates very slow and controlled flow [1]. For evaluation of the system, we used L929 mouse fibroblast cells and exposed them to a mechanical stress gradient and a chemical nutrient gradient at once.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages147-149
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - 2009
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: 2009 Nov 12009 Nov 5

Publication series

NameProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
CountryKorea, Republic of
CityJeju
Period09/11/109/11/5

Keywords

  • Interstitial flow
  • Microfluidics
  • Multiple gradients
  • Shear stress

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Yoo, S. J., Park, J. Y., Hwang, C. M., Jeong, G. S., & Lee, S. H. (2009). Simultaneous generation of chemical concentration and mechanical shear stress gradients in a microfluidic chip. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 147-149). (Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.