Simultaneous generation of chemical concentration and mechanical shear stress gradients in a microfluidic chip

Sung Ju Yoo, Joong Yull Park, Chang Mo Hwang, Gi Seok Jeong, Sang Hoon Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We describe a simple and versatile method to study the generation of chemical concentration and mechanical shear stress gradients in a single microfluidic chip. Our system uses an osmotic pump that generates very slow and controlled flow [1]. For evaluation of the system, we used L929 mouse fibroblast cells and exposed them to a mechanical stress gradient and a chemical nutrient gradient at once.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages147-149
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - 2009
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: 2009 Nov 12009 Nov 5

Publication series

NameProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
Country/TerritoryKorea, Republic of
CityJeju
Period09/11/109/11/5

Keywords

  • Interstitial flow
  • Microfluidics
  • Multiple gradients
  • Shear stress

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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