Simultaneous imaging of mitochondria and lysosomes by using two-photon fluorescent probes

Ji Hee Han, Sun Keun Park, Chang Su Lim, Min Kyu Park, Hyung Joong Kim, Hwan Myung Kim, Bong Rae Cho

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Dual-color imaging: Two-photon probes for lysosomes (BLT-blue) and mitochondria (FMT-green) that can be excited by 750 nm femtosecond laser pulses and emit at λ=400-450 and 550-600 nm, respectively, are reported. They allow simultaneous dual-color imaging of lysosomes and mitochondria in live cells and tissues for a long period of time with minimum interference from pH, photobleaching, or cytotoxicity (see scheme).

Original languageEnglish
Pages (from-to)15246-15249
Number of pages4
JournalChemistry - A European Journal
Volume18
Issue number48
DOIs
Publication statusPublished - 2012 Nov 26

Keywords

  • fluorescence
  • fluorescent probes
  • imaging agents
  • lysosomes
  • mitochondria

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Organic Chemistry

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