Simultaneous measurement of 23 plasma cytokines in late-life depression

Kang Soo Lee, Ji Hyung Chung, Kyung Hye Lee, Min Jeong Shin, Byoung Hoon Oh, Soo Hyung Lee, Chang Hyung Hong

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

According to the cytokine hypothesis of depression, cytokines play key roles in the behavioral, neuroendocrinal, and neurochemical features of depression. In this study, we used a bioplex assay to simultaneously measure the levels of 23 plasma cytokines in 18 patients with late-life depression and 38 normal controls, and these levels were compared between the two groups. The plasma interleukin-1alpha (IL-1α) levels were found to be significantly different between the two groups. After adjusting for age, gender, low-density lipoprotein cholesterol, and triglyceride, the plasma IL-1α levels were significantly higher in the patients with late-life depression than in the normal control subjects. Thus, this study provides preliminary evidence that plasma IL-1α may play important roles in the pathogenesis of late-life depression.

Original languageEnglish
Pages (from-to)435-438
Number of pages4
JournalNeurological Sciences
Volume30
Issue number5
DOIs
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • Bioplex
  • Cytokine
  • Interleukin-1 alpha
  • Late-life depression
  • Plasma
  • Vascular risk factors

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

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  • Cite this

    Lee, K. S., Chung, J. H., Lee, K. H., Shin, M. J., Oh, B. H., Lee, S. H., & Hong, C. H. (2009). Simultaneous measurement of 23 plasma cytokines in late-life depression. Neurological Sciences, 30(5), 435-438. https://doi.org/10.1007/s10072-009-0091-1