Simultaneous microfluidic spinning of multiple strands of submicron fiber for the production of free-standing porous membranes for biological application

Doyeun Park, Jisoo Park, Heeyeong Jang, Jie Cheng, Soo Hyun Kim, Sang Hoon Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Microfibers produced using electrospinning and microfluidics-based technologies have been developed as a powerful tool in tissue engineering applications such as drug delivery and scaffolds. The applications of these fibers, however, have been limited because of the hazardous solvents used to make them, difficulties in controlling the pore sizes of their membrane forms, and downscaling the size of the fiber. Nevertheless, extending the use of these fibers, for example in the production of a free-standing porous membrane appropriate for cell-based research, is highly needed for tissue engineering, organ-on-a-chip, and drug delivery research and applications. Here, we fabricated a free-standing porous membrane by using a novel method that involved simultaneously spinning multiple strands of submicron-thick 'noodle-like' fibers. In addition to the novelty of the single noodle fiber in overcoming the size-reducing limitations of conventional microfluidic spinning methods, these fibers can hence form the units of 'noodle membranes' whose pores have sizes that the convention electrospinning method cannot achieve. We confirmed the potential of the noodle membrane to serve as a free-standing porous membrane in two simple experiments. Also, we found that noodle membranes have an advantage in loading different amounts of different materials in itself that it was also shown to be of use as a new type of scaffold for complex tissue regeneration. Therefore, the proposed noodle membrane can be an effective tool in tissue engineering applications and biological studies.

Original languageEnglish
Article number025026
JournalBiofabrication
Volume9
Issue number2
DOIs
Publication statusPublished - 2017 Jun 1

Fingerprint

Microfluidics
Membranes
Fibers
Tissue Engineering
Tissue engineering
Electrospinning
Drug delivery
Tissue Scaffolds
Pore size
Research
Pharmaceutical Preparations
Membrane Potentials
Tissue regeneration
Regeneration
Scaffolds (biology)
Cell Membrane
Scaffolds
Technology

Keywords

  • free-standing porous membrane
  • microfiber spinning chip
  • noodle fiber
  • noodle membrane
  • tissue regeneration

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Biomaterials
  • Biomedical Engineering

Cite this

Simultaneous microfluidic spinning of multiple strands of submicron fiber for the production of free-standing porous membranes for biological application. / Park, Doyeun; Park, Jisoo; Jang, Heeyeong; Cheng, Jie; Kim, Soo Hyun; Lee, Sang Hoon.

In: Biofabrication, Vol. 9, No. 2, 025026, 01.06.2017.

Research output: Contribution to journalArticle

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