Single-enzyme nanoparticles armored by a nanometer-scale organic/inorganic network

Jungbae Kim, Jay W. Grate

Research output: Contribution to journalArticle

212 Citations (Scopus)

Abstract

We have developed armored single-enzyme nanoparticles (SENs) that surround each enzyme molecule with a porous composite organic/inorganic network of less than a few nanometers thick. This approach has significantly stabilized two proteases (α-chymotrypsin, CT, and trypsin, TR), and the armor network around CT is sufficiently thin and porous that it does not place a large mass-transfer limitation on the substrate. These new hybrid enzyme nanostructures offer great potential as a method to stabilize enzymes for various applications.

Original languageEnglish
Pages (from-to)1219-1222
Number of pages4
JournalNano Letters
Volume3
Issue number9
DOIs
Publication statusPublished - 2003 Sep 1
Externally publishedYes

Fingerprint

enzymes
Enzymes
Nanoparticles
nanoparticles
armor
trypsin
protease
Armor
Chymotrypsin
Trypsin
mass transfer
Nanostructures
Peptide Hydrolases
Mass transfer
Molecules
composite materials
Composite materials
Substrates
molecules

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Single-enzyme nanoparticles armored by a nanometer-scale organic/inorganic network. / Kim, Jungbae; Grate, Jay W.

In: Nano Letters, Vol. 3, No. 9, 01.09.2003, p. 1219-1222.

Research output: Contribution to journalArticle

@article{f774af9383f34a26b365eca970f95447,
title = "Single-enzyme nanoparticles armored by a nanometer-scale organic/inorganic network",
abstract = "We have developed armored single-enzyme nanoparticles (SENs) that surround each enzyme molecule with a porous composite organic/inorganic network of less than a few nanometers thick. This approach has significantly stabilized two proteases (α-chymotrypsin, CT, and trypsin, TR), and the armor network around CT is sufficiently thin and porous that it does not place a large mass-transfer limitation on the substrate. These new hybrid enzyme nanostructures offer great potential as a method to stabilize enzymes for various applications.",
author = "Jungbae Kim and Grate, {Jay W.}",
year = "2003",
month = "9",
day = "1",
doi = "10.1021/nl034404b",
language = "English",
volume = "3",
pages = "1219--1222",
journal = "Nano Letters",
issn = "1530-6984",
publisher = "American Chemical Society",
number = "9",

}

TY - JOUR

T1 - Single-enzyme nanoparticles armored by a nanometer-scale organic/inorganic network

AU - Kim, Jungbae

AU - Grate, Jay W.

PY - 2003/9/1

Y1 - 2003/9/1

N2 - We have developed armored single-enzyme nanoparticles (SENs) that surround each enzyme molecule with a porous composite organic/inorganic network of less than a few nanometers thick. This approach has significantly stabilized two proteases (α-chymotrypsin, CT, and trypsin, TR), and the armor network around CT is sufficiently thin and porous that it does not place a large mass-transfer limitation on the substrate. These new hybrid enzyme nanostructures offer great potential as a method to stabilize enzymes for various applications.

AB - We have developed armored single-enzyme nanoparticles (SENs) that surround each enzyme molecule with a porous composite organic/inorganic network of less than a few nanometers thick. This approach has significantly stabilized two proteases (α-chymotrypsin, CT, and trypsin, TR), and the armor network around CT is sufficiently thin and porous that it does not place a large mass-transfer limitation on the substrate. These new hybrid enzyme nanostructures offer great potential as a method to stabilize enzymes for various applications.

UR - http://www.scopus.com/inward/record.url?scp=0141684517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141684517&partnerID=8YFLogxK

U2 - 10.1021/nl034404b

DO - 10.1021/nl034404b

M3 - Article

VL - 3

SP - 1219

EP - 1222

JO - Nano Letters

JF - Nano Letters

SN - 1530-6984

IS - 9

ER -