Single pretreatment of remifentanil may reduce pain after propofol and rocuronium injection in rapid sequence induction

Yoon Ji Choi, Han Seok Park, Han Lee, Seung Zhoo Yoon

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: We designed this double-blind, placebo-controlled study to compare the efficacy of remifentanil in reducing the pain of both propofol and rocuronium injection during rapid-sequence induction. Methods: Ninety-five patients, scheduled for elective surgery under general anesthesia, were divided into 3 groups: saline (Group S, n = 31), remifentanil 1 μg/kg (Group R, n = 32), and lidocaine 1.5 mg/kg (Group L, n = 32) were administered after tourniquet application. The occlusion was released after 1 min and 5 ml of 1% propofol was injected over 10 s. Pain on propofol injection was evaluated by a 10-point verbal numeric rating scale (VNRS). The rest of the induction dose of propofol and 1 mg/kg of rocuronium, were injected. Pain on rocuronium injection was evaluated by a four-point score (FPS). Results: The VNRS of propofol injection was as follows: R (0.78) = L (1.34) < S (4.26). The incidence of withdrawal response due to rocuronium was as follows: R (6.3%) < L (53.1%) < S (83.9%). The FPS of rocuronium injection was as follows: R (0.81) < L (1.78) < S (2.93). Conclusions: Pretreatment with a bolus of remifentanil was effective in simultaneously reducing injection pain of propofol and rocuronium. In addition, remifentanil pretreatment was more effective in suppression of withdrawal response by rocuronium than lidocaine.

Original languageEnglish
Pages (from-to)413-418
Number of pages6
JournalKorean journal of anesthesiology
Volume63
Issue number5
DOIs
Publication statusPublished - 2012 Nov

Keywords

  • Injection pain
  • Lidocaine
  • Propofol
  • Remifentanil
  • Rocuronium

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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