Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli

William A. Rosche, Adam Jaworski, Seongman Kang, Shannon F. Kramer, Jacquelynn E. Larson, David P. Geidroc, Robert D. Wells, Richard R. Sinden

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The stability of CTG triplet repeats was analyzed in Escherichia coli to identify processes responsible for their genetic instability. Using a biochemical assay for stability, we show that the absence of single-stranded- DNA-binding protein leads to an increase in the frequency of large deletions within the triplet repeats.

Original languageEnglish
Pages (from-to)5042-5044
Number of pages3
JournalJournal of Bacteriology
Volume178
Issue number16
DOIs
Publication statusPublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli'. Together they form a unique fingerprint.

  • Cite this

    Rosche, W. A., Jaworski, A., Kang, S., Kramer, S. F., Larson, J. E., Geidroc, D. P., Wells, R. D., & Sinden, R. R. (1996). Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli. Journal of Bacteriology, 178(16), 5042-5044. https://doi.org/10.1128/jb.178.16.5042-5044.1996