The stability of CTG triplet repeats was analyzed in Escherichia coli to identify processes responsible for their genetic instability. Using a biochemical assay for stability, we show that the absence of single-stranded- DNA-binding protein leads to an increase in the frequency of large deletions within the triplet repeats.
|Number of pages||3|
|Journal||Journal of Bacteriology|
|Publication status||Published - 1996 Oct 7|
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology