SIRT1 expression is associated with good prognosis in colorectal cancer

Wonkyung Jung, Kwang Dae Hong, Woon Yong Jung, Eunjung Lee, Bong Kyung Shin, Han Kyeom Kim, Aeree Kim, Baek-Hui Kim

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Silent mating type information regulation 2 homolog 1 (SIRT1), an NAD+-dependent deacetylase, might act as a tumor promoter by inhibiting p53, but may also as a tumor suppressor by inhibiting several oncogenes such as ß-catenin and survivin. Deleted in breast cancer 1 (DBC1) is known as a negative regulator of SIRT1. Methods: Immunohistochemical expressions of SIRT1, DBC1, ß-catenin, surviving, and p53 were evaluated using 2 mm tumor cores from 349 colorectal cancer patients for tissue microarray. Results: Overexpression of SIRT1, DBC1, survivin, and p53 was seen in 235 (67%), 183 (52%), 193 (55%), and 190 (54%) patients, respectively. Altered expression of ß-catenin was identified in 246 (70%) patients. On univariate analysis, overexpression of SIRT1 (p=0.029) and altered expression of ß-catenin (p=0.008) were significantly associated with longer overall survival. Expression of SIRT1 was significantly related to DBC1 (p=0.001), ß-catenin (p=0.001), and survivin (p=0.002), but not with p53. On multivariate analysis, age, tumor stage, differentiation, and expression of SIRT1 were independent prognostic factors significantly associated with overall survival. Conclusions: SIRT1 overexpression is a good prognostic factor for colorectal cancer, and SIRT1 may interact with ß-catenin and survivin rather than p53.

Original languageEnglish
Pages (from-to)332-339
Number of pages8
JournalKorean Journal of Pathology
Volume47
Issue number4
DOIs
Publication statusPublished - 2013 Sep 30

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Catenins
Colorectal Neoplasms
Breast Neoplasms
Sirtuin 1
Neoplasms
Survival
Oncogenes
Carcinogens
NAD
Multivariate Analysis

Keywords

  • Adenocarcinoma
  • Beta catenin.
  • Colon
  • Dbc1
  • Sirt1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

SIRT1 expression is associated with good prognosis in colorectal cancer. / Jung, Wonkyung; Hong, Kwang Dae; Jung, Woon Yong; Lee, Eunjung; Shin, Bong Kyung; Kim, Han Kyeom; Kim, Aeree; Kim, Baek-Hui.

In: Korean Journal of Pathology, Vol. 47, No. 4, 30.09.2013, p. 332-339.

Research output: Contribution to journalArticle

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abstract = "Background: Silent mating type information regulation 2 homolog 1 (SIRT1), an NAD+-dependent deacetylase, might act as a tumor promoter by inhibiting p53, but may also as a tumor suppressor by inhibiting several oncogenes such as {\ss}-catenin and survivin. Deleted in breast cancer 1 (DBC1) is known as a negative regulator of SIRT1. Methods: Immunohistochemical expressions of SIRT1, DBC1, {\ss}-catenin, surviving, and p53 were evaluated using 2 mm tumor cores from 349 colorectal cancer patients for tissue microarray. Results: Overexpression of SIRT1, DBC1, survivin, and p53 was seen in 235 (67{\%}), 183 (52{\%}), 193 (55{\%}), and 190 (54{\%}) patients, respectively. Altered expression of {\ss}-catenin was identified in 246 (70{\%}) patients. On univariate analysis, overexpression of SIRT1 (p=0.029) and altered expression of {\ss}-catenin (p=0.008) were significantly associated with longer overall survival. Expression of SIRT1 was significantly related to DBC1 (p=0.001), {\ss}-catenin (p=0.001), and survivin (p=0.002), but not with p53. On multivariate analysis, age, tumor stage, differentiation, and expression of SIRT1 were independent prognostic factors significantly associated with overall survival. Conclusions: SIRT1 overexpression is a good prognostic factor for colorectal cancer, and SIRT1 may interact with {\ss}-catenin and survivin rather than p53.",
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AU - Lee, Eunjung

AU - Shin, Bong Kyung

AU - Kim, Han Kyeom

AU - Kim, Aeree

AU - Kim, Baek-Hui

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