SIRT1 expression is associated with good prognosis in colorectal cancer

Wonkyung Jung, Kwang Dae Hong, Woon Yong Jung, Eunjung Lee, Bong Kyung Shin, Han Kyeom Kim, Aeree Kim, Baek Hui Kim

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Silent mating type information regulation 2 homolog 1 (SIRT1), an NAD+-dependent deacetylase, might act as a tumor promoter by inhibiting p53, but may also as a tumor suppressor by inhibiting several oncogenes such as ß-catenin and survivin. Deleted in breast cancer 1 (DBC1) is known as a negative regulator of SIRT1. Methods: Immunohistochemical expressions of SIRT1, DBC1, ß-catenin, surviving, and p53 were evaluated using 2 mm tumor cores from 349 colorectal cancer patients for tissue microarray. Results: Overexpression of SIRT1, DBC1, survivin, and p53 was seen in 235 (67%), 183 (52%), 193 (55%), and 190 (54%) patients, respectively. Altered expression of ß-catenin was identified in 246 (70%) patients. On univariate analysis, overexpression of SIRT1 (p=0.029) and altered expression of ß-catenin (p=0.008) were significantly associated with longer overall survival. Expression of SIRT1 was significantly related to DBC1 (p=0.001), ß-catenin (p=0.001), and survivin (p=0.002), but not with p53. On multivariate analysis, age, tumor stage, differentiation, and expression of SIRT1 were independent prognostic factors significantly associated with overall survival. Conclusions: SIRT1 overexpression is a good prognostic factor for colorectal cancer, and SIRT1 may interact with ß-catenin and survivin rather than p53.

Original languageEnglish
Pages (from-to)332-339
Number of pages8
JournalKorean Journal of Pathology
Volume47
Issue number4
DOIs
Publication statusPublished - 2013 Sep 30

Keywords

  • Adenocarcinoma
  • Beta catenin.
  • Colon
  • Dbc1
  • Sirt1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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