Size-controlled self-aggregated N-acyl chitosan nanoparticles as a vitamin C carrier

Youngjin Cho, Jun Tae Kim, Hyun Jin Park

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

N-acyl chitosans with various acyl chain lengths were synthesized to improve their hydrophobicity and stability in delivery system. N-acyl chitosan nanoparticles were fabricated by self-aggregation method and vitamin C was loaded into the particles. Particle sizes were ranged from 444 nm to 487 nm with various acyl chain lengths reduced to particle size 216-288 nm with vitamin C loading. Vitamin C in the N-acyl chitosan nanoparticles may cross-link and pull the particle wall resulting in reducing the particle size. N-acyl chitosan nanoparticles were characterized using FTIR, zeta potential, size analyzer, scanning electron microscope. The loading efficiency of vitamin C on N-acyl chitosan nanoparticles ranged 55-67% and increased the loading efficiency of vitamin C too, with N-acyl chain length. Vitamin C in N-acyl chitosan nanoparticles showed the controlled release properties at pH 1.3 and pH 7.4. Release rate of vitamin C load is reduced with increasing the length of acyl side chain.

Original languageEnglish
Pages (from-to)1087-1092
Number of pages6
JournalCarbohydrate Polymers
Volume88
Issue number3
DOIs
Publication statusPublished - 2012 Apr 15

Fingerprint

Vitamins
Chitosan
Ascorbic Acid
Nanoparticles
Chain length
Particle size
Zeta potential
Hydrophobicity
Electron microscopes
Agglomeration
Scanning

Keywords

  • Delivery system
  • N-acyl chitosan
  • Nanoparticle
  • Self-aggregation method
  • Vitamin C

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Size-controlled self-aggregated N-acyl chitosan nanoparticles as a vitamin C carrier. / Cho, Youngjin; Kim, Jun Tae; Park, Hyun Jin.

In: Carbohydrate Polymers, Vol. 88, No. 3, 15.04.2012, p. 1087-1092.

Research output: Contribution to journalArticle

@article{af8225529e5648578c1a34a6173329cb,
title = "Size-controlled self-aggregated N-acyl chitosan nanoparticles as a vitamin C carrier",
abstract = "N-acyl chitosans with various acyl chain lengths were synthesized to improve their hydrophobicity and stability in delivery system. N-acyl chitosan nanoparticles were fabricated by self-aggregation method and vitamin C was loaded into the particles. Particle sizes were ranged from 444 nm to 487 nm with various acyl chain lengths reduced to particle size 216-288 nm with vitamin C loading. Vitamin C in the N-acyl chitosan nanoparticles may cross-link and pull the particle wall resulting in reducing the particle size. N-acyl chitosan nanoparticles were characterized using FTIR, zeta potential, size analyzer, scanning electron microscope. The loading efficiency of vitamin C on N-acyl chitosan nanoparticles ranged 55-67{\%} and increased the loading efficiency of vitamin C too, with N-acyl chain length. Vitamin C in N-acyl chitosan nanoparticles showed the controlled release properties at pH 1.3 and pH 7.4. Release rate of vitamin C load is reduced with increasing the length of acyl side chain.",
keywords = "Delivery system, N-acyl chitosan, Nanoparticle, Self-aggregation method, Vitamin C",
author = "Youngjin Cho and Kim, {Jun Tae} and Park, {Hyun Jin}",
year = "2012",
month = "4",
day = "15",
doi = "10.1016/j.carbpol.2012.01.074",
language = "English",
volume = "88",
pages = "1087--1092",
journal = "Carbohydrate Polymers",
issn = "0144-8617",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Size-controlled self-aggregated N-acyl chitosan nanoparticles as a vitamin C carrier

AU - Cho, Youngjin

AU - Kim, Jun Tae

AU - Park, Hyun Jin

PY - 2012/4/15

Y1 - 2012/4/15

N2 - N-acyl chitosans with various acyl chain lengths were synthesized to improve their hydrophobicity and stability in delivery system. N-acyl chitosan nanoparticles were fabricated by self-aggregation method and vitamin C was loaded into the particles. Particle sizes were ranged from 444 nm to 487 nm with various acyl chain lengths reduced to particle size 216-288 nm with vitamin C loading. Vitamin C in the N-acyl chitosan nanoparticles may cross-link and pull the particle wall resulting in reducing the particle size. N-acyl chitosan nanoparticles were characterized using FTIR, zeta potential, size analyzer, scanning electron microscope. The loading efficiency of vitamin C on N-acyl chitosan nanoparticles ranged 55-67% and increased the loading efficiency of vitamin C too, with N-acyl chain length. Vitamin C in N-acyl chitosan nanoparticles showed the controlled release properties at pH 1.3 and pH 7.4. Release rate of vitamin C load is reduced with increasing the length of acyl side chain.

AB - N-acyl chitosans with various acyl chain lengths were synthesized to improve their hydrophobicity and stability in delivery system. N-acyl chitosan nanoparticles were fabricated by self-aggregation method and vitamin C was loaded into the particles. Particle sizes were ranged from 444 nm to 487 nm with various acyl chain lengths reduced to particle size 216-288 nm with vitamin C loading. Vitamin C in the N-acyl chitosan nanoparticles may cross-link and pull the particle wall resulting in reducing the particle size. N-acyl chitosan nanoparticles were characterized using FTIR, zeta potential, size analyzer, scanning electron microscope. The loading efficiency of vitamin C on N-acyl chitosan nanoparticles ranged 55-67% and increased the loading efficiency of vitamin C too, with N-acyl chain length. Vitamin C in N-acyl chitosan nanoparticles showed the controlled release properties at pH 1.3 and pH 7.4. Release rate of vitamin C load is reduced with increasing the length of acyl side chain.

KW - Delivery system

KW - N-acyl chitosan

KW - Nanoparticle

KW - Self-aggregation method

KW - Vitamin C

UR - http://www.scopus.com/inward/record.url?scp=84862819036&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862819036&partnerID=8YFLogxK

U2 - 10.1016/j.carbpol.2012.01.074

DO - 10.1016/j.carbpol.2012.01.074

M3 - Article

VL - 88

SP - 1087

EP - 1092

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

IS - 3

ER -