Size-controlled self-aggregated N-acyl chitosan nanoparticles as a vitamin C carrier

Youngjin Cho, Jun Tae Kim, Hyun Jin Park

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

N-acyl chitosans with various acyl chain lengths were synthesized to improve their hydrophobicity and stability in delivery system. N-acyl chitosan nanoparticles were fabricated by self-aggregation method and vitamin C was loaded into the particles. Particle sizes were ranged from 444 nm to 487 nm with various acyl chain lengths reduced to particle size 216-288 nm with vitamin C loading. Vitamin C in the N-acyl chitosan nanoparticles may cross-link and pull the particle wall resulting in reducing the particle size. N-acyl chitosan nanoparticles were characterized using FTIR, zeta potential, size analyzer, scanning electron microscope. The loading efficiency of vitamin C on N-acyl chitosan nanoparticles ranged 55-67% and increased the loading efficiency of vitamin C too, with N-acyl chain length. Vitamin C in N-acyl chitosan nanoparticles showed the controlled release properties at pH 1.3 and pH 7.4. Release rate of vitamin C load is reduced with increasing the length of acyl side chain.

Original languageEnglish
Pages (from-to)1087-1092
Number of pages6
JournalCarbohydrate Polymers
Volume88
Issue number3
DOIs
Publication statusPublished - 2012 Apr 15

Keywords

  • Delivery system
  • N-acyl chitosan
  • Nanoparticle
  • Self-aggregation method
  • Vitamin C

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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