Sjögren's syndrome with acute renal failure

Young-Joo Kwon, Jae Hong Park, Sang Wook Kim, Sang Youb Han, Heui Jung Pyo, Nam Hee Won

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We experienced a 65-year-old woman with Sjögren's syndrome who presented with acute renal failure, hypergammaglobulinemia with monoclonal gammopathy, and hypocomplementemia. She improved with steroid pulse therapy (methylprednisolone 0.5 g/day for 3 days). This patient had also sensorineural hearing loss, symmetric sensory polyneuropathy of legs, and interstitial lung disease. Ten months after recovery from acute renal failure, low-dose oral prednisolone (0.1 mg/kg/day) was withdrawn. On the third month of steroid withdrawal, acute renal failure recurred with hypergammaglobulinemia, hyperamylasemia, and autoimmune cholangitis-like biochemical derangements, which also responded to steroid pulse therapy (methylprednisolone 0.3 g/day for 3 days). When we would withdraw steroid in a patient with visceral involvement of Sjögren's syndrome, we should consider multiple clinical and laboratorial variables, including erythrocyte sedimentation rate, serum levels of IgG, total protein, C3/C4, CRP, amylase, lipase, and alkaline phosphatase. We report this case which exhibited various unusual manifestations with a review of literature.

Original languageEnglish
Pages (from-to)665-669
Number of pages5
JournalJournal of Korean Medical Science
Volume13
Issue number6
Publication statusPublished - 1998 Dec 1

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Acute Kidney Injury
Steroids
Hypergammaglobulinemia
Methylprednisolone
Hyperamylasemia
Paraproteinemias
Cholangitis
Polyneuropathies
Sensorineural Hearing Loss
Blood Sedimentation
Interstitial Lung Diseases
Amylases
Prednisolone
Lipase
Alkaline Phosphatase
Leg
Immunoglobulin G
Therapeutics
Serum
Proteins

Keywords

  • Amylases
  • Complement
  • Kidney failure, acute
  • Paraproteinemias (monoclonal gammopathy)
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kwon, Y-J., Park, J. H., Kim, S. W., Han, S. Y., Pyo, H. J., & Won, N. H. (1998). Sjögren's syndrome with acute renal failure. Journal of Korean Medical Science, 13(6), 665-669.

Sjögren's syndrome with acute renal failure. / Kwon, Young-Joo; Park, Jae Hong; Kim, Sang Wook; Han, Sang Youb; Pyo, Heui Jung; Won, Nam Hee.

In: Journal of Korean Medical Science, Vol. 13, No. 6, 01.12.1998, p. 665-669.

Research output: Contribution to journalArticle

Kwon, Y-J, Park, JH, Kim, SW, Han, SY, Pyo, HJ & Won, NH 1998, 'Sjögren's syndrome with acute renal failure', Journal of Korean Medical Science, vol. 13, no. 6, pp. 665-669.
Kwon Y-J, Park JH, Kim SW, Han SY, Pyo HJ, Won NH. Sjögren's syndrome with acute renal failure. Journal of Korean Medical Science. 1998 Dec 1;13(6):665-669.
Kwon, Young-Joo ; Park, Jae Hong ; Kim, Sang Wook ; Han, Sang Youb ; Pyo, Heui Jung ; Won, Nam Hee. / Sjögren's syndrome with acute renal failure. In: Journal of Korean Medical Science. 1998 ; Vol. 13, No. 6. pp. 665-669.
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