Sjögren's syndrome with acute renal failure

Young Joo Kwon, Jae Hong Park, Sang Wook Kim, Sang Youb Han, Heui Jung Pyo, Nam Hee Won

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We experienced a 65-year-old woman with Sjögren's syndrome who presented with acute renal failure, hypergammaglobulinemia with monoclonal gammopathy, and hypocomplementemia. She improved with steroid pulse therapy (methylprednisolone 0.5 g/day for 3 days). This patient had also sensorineural hearing loss, symmetric sensory polyneuropathy of legs, and interstitial lung disease. Ten months after recovery from acute renal failure, low-dose oral prednisolone (0.1 mg/kg/day) was withdrawn. On the third month of steroid withdrawal, acute renal failure recurred with hypergammaglobulinemia, hyperamylasemia, and autoimmune cholangitis-like biochemical derangements, which also responded to steroid pulse therapy (methylprednisolone 0.3 g/day for 3 days). When we would withdraw steroid in a patient with visceral involvement of Sjögren's syndrome, we should consider multiple clinical and laboratorial variables, including erythrocyte sedimentation rate, serum levels of IgG, total protein, C3/C4, CRP, amylase, lipase, and alkaline phosphatase. We report this case which exhibited various unusual manifestations with a review of literature.

Original languageEnglish
Pages (from-to)665-669
Number of pages5
JournalJournal of Korean medical science
Volume13
Issue number6
DOIs
Publication statusPublished - 1998 Dec

Keywords

  • Amylases
  • Complement
  • Kidney failure, acute
  • Paraproteinemias (monoclonal gammopathy)
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Kwon, Y. J., Park, J. H., Kim, S. W., Han, S. Y., Pyo, H. J., & Won, N. H. (1998). Sjögren's syndrome with acute renal failure. Journal of Korean medical science, 13(6), 665-669. https://doi.org/10.3346/jkms.1998.13.6.665