Skeletal muscle mass to visceral fat area ratio is associated with metabolic syndrome and arterial stiffness: The Korean Sarcopenic Obesity Study (KSOS)

Tae Nyun Kim, Man Sik Park, Kang Il Lim, Sae Jeong Yang, Hye-Jin Yoo, Hyun Joo Kang, Wook Song, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Sei-Hyun Baik, Dong Seop Choi, Kyung Mook Choi

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Aims: Sarcopenia measured as appendicular skeletal muscle mass (ASM), and central obesity measured as visceral fat area (VFA) may act synergistically to influence metabolic syndrome and atherosclerosis. However, several previous studies reported that metabolic risk is higher in non-sarcopenic obesity groups than in sarcopenic obesity groups because of the close relationship between muscle mass and body fat. We investigated the association of the ASM to VFA ratio, which we have termed the muscle-to-fat ratio (MFR), with metabolic syndrome and arterial stiffness. Methods: This study was performed in 526 apparently healthy adults enrolled in the Korean Sarcopenic Obesity Study, an ongoing prospective observational cohort study. ASM was evaluated with dual energy X-ray absorptiometry and VFA with computed tomography. Arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV). Results: MFR was significantly associated with waist circumference, blood pressure, lipid profiles, glucose and baPWV. By multiple logistic regression analysis, the odds ratio for metabolic syndrome was 5.43 (lowest versus highest tertile of MFR, 95% confidence interval, 2.56-13.34). Multiple stepwise regression analysis showed that MFR was an independent determinant of baPWV (R 2=0.57). Conclusions: MFR, a new index of sarcopenic obesity, showed an independent negative association with metabolic syndrome and arterial stiffness.

Original languageEnglish
Pages (from-to)285-291
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume93
Issue number2
DOIs
Publication statusPublished - 2011 Aug 1

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Vascular Stiffness
Intra-Abdominal Fat
Skeletal Muscle
Obesity
Muscles
Fats
Pulse Wave Analysis
Ankle
Arm
Regression Analysis
Sarcopenia
Abdominal Obesity
Photon Absorptiometry
Waist Circumference
Observational Studies
Adipose Tissue
Atherosclerosis
Cohort Studies
Logistic Models
Odds Ratio

Keywords

  • Arterial stiffness
  • Metabolic syndrome
  • Pulse wave velocity
  • Sarcopenia
  • Sarcopenic obesity

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Skeletal muscle mass to visceral fat area ratio is associated with metabolic syndrome and arterial stiffness : The Korean Sarcopenic Obesity Study (KSOS). / Kim, Tae Nyun; Park, Man Sik; Lim, Kang Il; Yang, Sae Jeong; Yoo, Hye-Jin; Kang, Hyun Joo; Song, Wook; Seo, Ji A; Kim, Sin Gon; Kim, Nan Hee; Baik, Sei-Hyun; Choi, Dong Seop; Choi, Kyung Mook.

In: Diabetes Research and Clinical Practice, Vol. 93, No. 2, 01.08.2011, p. 285-291.

Research output: Contribution to journalArticle

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abstract = "Aims: Sarcopenia measured as appendicular skeletal muscle mass (ASM), and central obesity measured as visceral fat area (VFA) may act synergistically to influence metabolic syndrome and atherosclerosis. However, several previous studies reported that metabolic risk is higher in non-sarcopenic obesity groups than in sarcopenic obesity groups because of the close relationship between muscle mass and body fat. We investigated the association of the ASM to VFA ratio, which we have termed the muscle-to-fat ratio (MFR), with metabolic syndrome and arterial stiffness. Methods: This study was performed in 526 apparently healthy adults enrolled in the Korean Sarcopenic Obesity Study, an ongoing prospective observational cohort study. ASM was evaluated with dual energy X-ray absorptiometry and VFA with computed tomography. Arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV). Results: MFR was significantly associated with waist circumference, blood pressure, lipid profiles, glucose and baPWV. By multiple logistic regression analysis, the odds ratio for metabolic syndrome was 5.43 (lowest versus highest tertile of MFR, 95{\%} confidence interval, 2.56-13.34). Multiple stepwise regression analysis showed that MFR was an independent determinant of baPWV (R 2=0.57). Conclusions: MFR, a new index of sarcopenic obesity, showed an independent negative association with metabolic syndrome and arterial stiffness.",
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T2 - The Korean Sarcopenic Obesity Study (KSOS)

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AU - Park, Man Sik

AU - Lim, Kang Il

AU - Yang, Sae Jeong

AU - Yoo, Hye-Jin

AU - Kang, Hyun Joo

AU - Song, Wook

AU - Seo, Ji A

AU - Kim, Sin Gon

AU - Kim, Nan Hee

AU - Baik, Sei-Hyun

AU - Choi, Dong Seop

AU - Choi, Kyung Mook

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N2 - Aims: Sarcopenia measured as appendicular skeletal muscle mass (ASM), and central obesity measured as visceral fat area (VFA) may act synergistically to influence metabolic syndrome and atherosclerosis. However, several previous studies reported that metabolic risk is higher in non-sarcopenic obesity groups than in sarcopenic obesity groups because of the close relationship between muscle mass and body fat. We investigated the association of the ASM to VFA ratio, which we have termed the muscle-to-fat ratio (MFR), with metabolic syndrome and arterial stiffness. Methods: This study was performed in 526 apparently healthy adults enrolled in the Korean Sarcopenic Obesity Study, an ongoing prospective observational cohort study. ASM was evaluated with dual energy X-ray absorptiometry and VFA with computed tomography. Arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV). Results: MFR was significantly associated with waist circumference, blood pressure, lipid profiles, glucose and baPWV. By multiple logistic regression analysis, the odds ratio for metabolic syndrome was 5.43 (lowest versus highest tertile of MFR, 95% confidence interval, 2.56-13.34). Multiple stepwise regression analysis showed that MFR was an independent determinant of baPWV (R 2=0.57). Conclusions: MFR, a new index of sarcopenic obesity, showed an independent negative association with metabolic syndrome and arterial stiffness.

AB - Aims: Sarcopenia measured as appendicular skeletal muscle mass (ASM), and central obesity measured as visceral fat area (VFA) may act synergistically to influence metabolic syndrome and atherosclerosis. However, several previous studies reported that metabolic risk is higher in non-sarcopenic obesity groups than in sarcopenic obesity groups because of the close relationship between muscle mass and body fat. We investigated the association of the ASM to VFA ratio, which we have termed the muscle-to-fat ratio (MFR), with metabolic syndrome and arterial stiffness. Methods: This study was performed in 526 apparently healthy adults enrolled in the Korean Sarcopenic Obesity Study, an ongoing prospective observational cohort study. ASM was evaluated with dual energy X-ray absorptiometry and VFA with computed tomography. Arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV). Results: MFR was significantly associated with waist circumference, blood pressure, lipid profiles, glucose and baPWV. By multiple logistic regression analysis, the odds ratio for metabolic syndrome was 5.43 (lowest versus highest tertile of MFR, 95% confidence interval, 2.56-13.34). Multiple stepwise regression analysis showed that MFR was an independent determinant of baPWV (R 2=0.57). Conclusions: MFR, a new index of sarcopenic obesity, showed an independent negative association with metabolic syndrome and arterial stiffness.

KW - Arterial stiffness

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KW - Pulse wave velocity

KW - Sarcopenia

KW - Sarcopenic obesity

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