Sleep Duration, Sleep Apnea, and Gray Matter Volume

Regina Eun Young Kim, Robert Douglas Abbott, Soriul Kim, Robert Joseph Thomas, Chang Ho Yun, Hyun Kim, Hans Johnson, Chol Shin

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


This study aimed to evaluate the effect of sleep duration on brain structures in the presence versus absence of sleep apnea in middle-aged and older individuals. The study investigated a population-based sample of 2,560 individuals, aged 49-80 years. The presence of sleep apnea and self-reported sleep duration were examined in relation to gray matter volume (GMV) in total and lobar brain regions. We identified ranges of sleep duration associated with maximal GMV using quadratic regression and bootstrap sampling. A significant quadratic association between sleep duration and GMV was observed in total and lobar brain regions of men with sleep apnea. In the fully adjusted model, optimal sleep durations associated with peak GMV between brain regions ranged from 6.7 to 7.0 hours. Shorter and longer sleep durations were associated with lower GMV in total and 4 sub-regions of the brain in men with sleep apnea.

Original languageEnglish
Pages (from-to)47-56
Number of pages10
JournalJournal of Geriatric Psychiatry and Neurology
Issue number1
Publication statusPublished - 2022 Jan
Externally publishedYes


  • MRI
  • aging
  • sleep apnea
  • sleep duration

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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