@article{2235faa6abe74b0396af59cd21cac34d,
title = "Sleep Duration, Sleep Apnea, and Gray Matter Volume",
abstract = "This study aimed to evaluate the effect of sleep duration on brain structures in the presence versus absence of sleep apnea in middle-aged and older individuals. The study investigated a population-based sample of 2,560 individuals, aged 49-80 years. The presence of sleep apnea and self-reported sleep duration were examined in relation to gray matter volume (GMV) in total and lobar brain regions. We identified ranges of sleep duration associated with maximal GMV using quadratic regression and bootstrap sampling. A significant quadratic association between sleep duration and GMV was observed in total and lobar brain regions of men with sleep apnea. In the fully adjusted model, optimal sleep durations associated with peak GMV between brain regions ranged from 6.7 to 7.0 hours. Shorter and longer sleep durations were associated with lower GMV in total and 4 sub-regions of the brain in men with sleep apnea.",
keywords = "MRI, aging, sleep apnea, sleep duration",
author = "Kim, {Regina Eun Young} and Abbott, {Robert Douglas} and Soriul Kim and Thomas, {Robert Joseph} and Yun, {Chang Ho} and Hyun Kim and Hans Johnson and Chol Shin",
note = "Funding Information: The authors would like to acknowledge Hye-Ryeong Nam, Sol Park, Seung Gu Lee, and members of the KoGES research team for their assistance in completing the analyses. This research was supported by funds from the Korea Centers for Disease Control and Prevention (2011-E71004-00, 2012-E71005-00, 2013-E71005-00, and 2014-E71003-00), the Ministry of Science, ICT & Future Planning (No. 2012e0009830), the Brain Pool Program from the National Research Foundation of Korea (No. NRF-2019H1D3A2A01101353), basic research from the National Research Foundation of Korea (No. NRF-2017R1D1A1B03033949), and in part through computational resources provided by The University of Iowa, Iowa City, Iowa. Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by funds from the Korea Centers for Disease Control and Prevention (2011-E71004-00, 2012-E71005-00, 2013-E71005-00, and 2014-E71003-00), the Ministry of Science, ICT & Future Planning (No. 2012e0009830), the Brain Pool Program from the National Research Foundation of Korea (No. NRF-2019H1D3A2A01101353), basic research from the National Research Foundation of Korea (No. NRF-2017R1D1A1B03033949), and in part through computational resources provided by The University of Iowa, Iowa City, Iowa. Publisher Copyright: {\textcopyright} The Author(s) 2021.",
year = "2022",
month = jan,
doi = "10.1177/0891988720988918",
language = "English",
volume = "35",
pages = "47--56",
journal = "Journal of Geriatric Psychiatry and Neurology",
issn = "0891-9887",
publisher = "SAGE Publications Inc.",
number = "1",
}
