Sleep-inducing effect of lettuce (Lactuca sativa) varieties on pentobarbital-induced sleep

Hae Dun Kim, Ki Bae Hong, Dong Ouk Noh, Hyung Joo Suh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The objective of this study was to investigate the sleep-inducing effect of lettuce varieties and the extracts derived from romaine lettuce on pentobarbital-induced sleep. Romaine lettuce had a higher lactucin content (red romaine: 361.50 µg/g of extract, green romaine: 1071.67 µg/g of extract) compared to the green and red lettuce varieties. The seed and leaf extracts derived from romaine lettuce induced an increase in the sleep duration at low and high doses respectively. The seed extract of romaine lettuce showed higher content of polyphenols, including caftaric acid, chlorogenic acid, and chicoric acid, compared to the leaf extract. The IC50 value of the leaf extract for its DPPH radical-scavenging was significantly less (0.11 mg/mL) than that of the seed extract (0.21 mg/mL) (p < 0.05). Romaine lettuce is an interesting and valuable source of sleep potentiating material and contains antioxidant phenolics that protect from the oxidant stress caused by sleep disturbance.

Original languageEnglish
Pages (from-to)807-814
Number of pages8
JournalFood Science and Biotechnology
Volume26
Issue number3
DOIs
Publication statusPublished - 2017 Jun 1

Fingerprint

romaine lettuce
Lettuce
pentobarbital
Lactuca sativa
Pentobarbital
sleep
lettuce
Sleep
seed extracts
leaf extracts
extracts
caftaric acid
Seeds
chlorogenic acid
oxidants
Chlorogenic Acid
inhibitory concentration 50
polyphenols
Cotyledon
Polyphenols

Keywords

  • Anti-radical
  • Lactuca sativa
  • Lettuce
  • Sleep

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

Cite this

Sleep-inducing effect of lettuce (Lactuca sativa) varieties on pentobarbital-induced sleep. / Kim, Hae Dun; Hong, Ki Bae; Noh, Dong Ouk; Suh, Hyung Joo.

In: Food Science and Biotechnology, Vol. 26, No. 3, 01.06.2017, p. 807-814.

Research output: Contribution to journalArticle

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