Sleep quality change after upper airway surgery in obstructive sleep apnea

Electrocardiogram-based cardiopulmonary coupling analysis

Ji Ho Choi, Chang Ho Yun, Robert J. Thomas, Soo Yeon Suh, Il Ho Park, Tae-Hoon Kim, Sang Hag Lee, Heung Man Lee, Seung Hoon Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives/Hypothesis To test the effect of upper airway surgery on sleep quality in adults with obstructive sleep apnea (OSA) and the potential usefulness of electrocardiogram (ECG)-based cardiopulmonary coupling (CPC) analysis as metrics of sleep quality. Study Design Retrospective outcome research. Methods A total of 62 consecutive adult patients with OSA, consisting of 36 with successful and 26 with unsuccessful outcomes, were included in the study. Mean age was 37.7 ± 8.9 years, and body mass index (BMI, kg/m<sup>2</sup>) was 26.9 ± 2.3. We compared clinical characteristics (age, BMI, and Epworth Sleepiness Scale [ESS]), sleep (sleep efficiency, stage non-rapid eye movement [N]1, N2, N3, rapid eye movement, and arousal index [ArI]), respiratory (apnea index [AI], apnea-hypopnea index [AHI], and minimum arterial oxygen saturation [SaO<inf>2</inf>]), and CPC (high-frequency coupling [HFC], low frequency coupling [LFC], very-low-frequency coupling, and elevated low-frequency coupling [e-LFC]) parameters between the success and nonsuccess groups before and after surgery. Surgical success was defined when the postoperative AHI was both <20 per hour and 50% of the preoperative value. Results Sleep quality measured by CPC analysis improved significantly (HFC, P = .001; LFC, P = .002; e-LFC, P = .003), along with parallel reduction in ESS, respiratory parameters (AHI, AI, minimum SaO<inf>2</inf>), and sleep fragmentation (ArI) in the group with surgical success after upper airway surgery. Conclusions Successful upper airway surgery can improve objective sleep quality in adult patients with OSA. CPC metrics of sleep quality are potentially useful to monitor therapeutic responses during long-term postoperative follow-up, as the ECG-based analysis is available as a standalone option outside laboratory polysomnography.

Original languageEnglish
Pages (from-to)1737-1742
Number of pages6
JournalLaryngoscope
Volume125
Issue number7
DOIs
Publication statusPublished - 2015 Jul 1

Fingerprint

Obstructive Sleep Apnea
Sleep
Electrocardiography
Apnea
Arousal
Sleep Deprivation
Polysomnography
Sleep Stages
REM Sleep
Eye Movements
Body Mass Index
Retrospective Studies
Outcome Assessment (Health Care)
Oxygen

Keywords

  • Cardiopulmonary coupling
  • obstructive sleep apnea
  • polysomnography
  • sleep quality
  • surgery

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Medicine(all)

Cite this

Sleep quality change after upper airway surgery in obstructive sleep apnea : Electrocardiogram-based cardiopulmonary coupling analysis. / Choi, Ji Ho; Yun, Chang Ho; Thomas, Robert J.; Suh, Soo Yeon; Park, Il Ho; Kim, Tae-Hoon; Lee, Sang Hag; Lee, Heung Man; Lee, Seung Hoon.

In: Laryngoscope, Vol. 125, No. 7, 01.07.2015, p. 1737-1742.

Research output: Contribution to journalArticle

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abstract = "Objectives/Hypothesis To test the effect of upper airway surgery on sleep quality in adults with obstructive sleep apnea (OSA) and the potential usefulness of electrocardiogram (ECG)-based cardiopulmonary coupling (CPC) analysis as metrics of sleep quality. Study Design Retrospective outcome research. Methods A total of 62 consecutive adult patients with OSA, consisting of 36 with successful and 26 with unsuccessful outcomes, were included in the study. Mean age was 37.7 ± 8.9 years, and body mass index (BMI, kg/m2) was 26.9 ± 2.3. We compared clinical characteristics (age, BMI, and Epworth Sleepiness Scale [ESS]), sleep (sleep efficiency, stage non-rapid eye movement [N]1, N2, N3, rapid eye movement, and arousal index [ArI]), respiratory (apnea index [AI], apnea-hypopnea index [AHI], and minimum arterial oxygen saturation [SaO2]), and CPC (high-frequency coupling [HFC], low frequency coupling [LFC], very-low-frequency coupling, and elevated low-frequency coupling [e-LFC]) parameters between the success and nonsuccess groups before and after surgery. Surgical success was defined when the postoperative AHI was both <20 per hour and 50{\%} of the preoperative value. Results Sleep quality measured by CPC analysis improved significantly (HFC, P = .001; LFC, P = .002; e-LFC, P = .003), along with parallel reduction in ESS, respiratory parameters (AHI, AI, minimum SaO2), and sleep fragmentation (ArI) in the group with surgical success after upper airway surgery. Conclusions Successful upper airway surgery can improve objective sleep quality in adult patients with OSA. CPC metrics of sleep quality are potentially useful to monitor therapeutic responses during long-term postoperative follow-up, as the ECG-based analysis is available as a standalone option outside laboratory polysomnography.",
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AU - Suh, Soo Yeon

AU - Park, Il Ho

AU - Kim, Tae-Hoon

AU - Lee, Sang Hag

AU - Lee, Heung Man

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