Slow dendritic transport of dissociated mouse hippocampal neurons exposed to aluminum

Ikuro Wakayama, Ki Joon Song, Vivek R. Nerurkar, Sohei Yoshida, Ralph M. Garruto

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    We determined the influence of aluminum on dendritic transport, using an in vitro system of dissociated mouse hippocampal neurons. Newly synthesized RNA from dissociated mouse hippocampal neurons was more slowly transported into dendrites in the presence of aluminum chloride when compared to those without the addition of aluminum chloride to the culture medium. Suppression of dendritic transport of newly synthesized RNA may be responsible for the dendritic degeneration observed in aluminum neurotoxicity, eventually leading to neuronal degeneration.

    Original languageEnglish
    Pages (from-to)237-240
    Number of pages4
    JournalBrain Research
    Volume748
    Issue number1-2
    DOIs
    Publication statusPublished - 1997 Feb 14

    Keywords

    • Alzheimer's disease
    • Guam
    • RNA
    • amyotrophic lateral sclerosis
    • axonal transport
    • cell culture
    • neurotoxin
    • parkinsonism-dementia

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Molecular Biology
    • Clinical Neurology
    • Developmental Biology

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