Slow dendritic transport of dissociated mouse hippocampal neurons exposed to aluminum

Ikuro Wakayama, Ki-Joon Song, Vivek R. Nerurkar, Sohei Yoshida, Ralph M. Garruto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We determined the influence of aluminum on dendritic transport, using an in vitro system of dissociated mouse hippocampal neurons. Newly synthesized RNA from dissociated mouse hippocampal neurons was more slowly transported into dendrites in the presence of aluminum chloride when compared to those without the addition of aluminum chloride to the culture medium. Suppression of dendritic transport of newly synthesized RNA may be responsible for the dendritic degeneration observed in aluminum neurotoxicity, eventually leading to neuronal degeneration.

Original languageEnglish
Pages (from-to)237-240
Number of pages4
JournalBrain Research
Volume748
Issue number1-2
DOIs
Publication statusPublished - 1997 Feb 14

Keywords

  • Alzheimer's disease
  • amyotrophic lateral sclerosis
  • axonal transport
  • cell culture
  • Guam
  • neurotoxin
  • parkinsonism-dementia
  • RNA

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

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