Slowly-Migrating α-Synuclein Forms Are Found in the Brains of Patients with Parkinsons Disease

Ju Youn Choi, Young Mo Sung, Hyo Jin Park, Eun Hye Hur, Ji Youn Kim, Eui Yul Choi, Jinseu Park, Byung Re Min, Seongman Kang, Hyangshuk Rhim

Research output: Contribution to journalArticle

Abstract

α-Synuclein is a pivotal genetic factor implicated in the pathogenesis of Parkinsons disease (PD), since pathogenic α-synuclein gene mutations occur in rare familial PD and wild-type α-synuclein appears to be a major component of Lewy bodies observed in PD. The main goal of this study was to determine whether the expression patterns of α-synuclein are differentially affected in the brains of PD, compared to normal controls. Here, we showed that new forms of the slowly-migrating α-synuclein were detected from the striatum, a region selectively affected in PD, in the brain of the patients with PD, but not from cerebellum of PD and normal controls. Moreover, these forms of α-synuclein were observed from the right brain that has a unilateral 6-hydroxydopamine lesioned nigrostriatal system in a rat model of PD. The results suggest that the new differential alteration in α-synuclein might be associated with the pathogenesis of PD.

Original languageEnglish
Pages (from-to)393-400
Number of pages8
JournalKorean Journal of Genetics
Volume23
Issue number4
Publication statusPublished - 2001 Dec

Keywords

  • Parkinsons disease
  • Pathogenesis
  • Slowly-migrating forms
  • α-synuclein

ASJC Scopus subject areas

  • Genetics

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    Choi, J. Y., Sung, Y. M., Park, H. J., Hur, E. H., Kim, J. Y., Choi, E. Y., Park, J., Min, B. R., Kang, S., & Rhim, H. (2001). Slowly-Migrating α-Synuclein Forms Are Found in the Brains of Patients with Parkinsons Disease. Korean Journal of Genetics, 23(4), 393-400.