Small-animal PET imaging analysis with [18F]FHBG in a mouse model of HSV1-tk gene expression in melanoma

Onseok Lee, Jaeyoung Kim, Chil Hwan Oh

    Research output: Contribution to journalLetterpeer-review

    1 Citation (Scopus)

    Abstract

    The purpose of this study was to establish a small-animal model for molecular imaging and to acquire basic data on assessing the efficacy of candidate melanoma drugs using small-animal PET imaging analysis with [18F]FHBG for herpes simplex virus 1-thymidine kinase (HSV1-tk) gene expression in a melanoma mouse model. The B16 melanoma cell line was transduced with a recombinant lentiviral vector containing the HSV1-tk gene and inoculated into the back skin of C57BL/6J mice. [18F]FHBG PET imaging showed better contrast for HSV1-tk(+) melanomas compared to brain, heart, gall bladder, intestine and kidney than did [18F]FDG PET imaging.

    Original languageEnglish
    Pages (from-to)199-201
    Number of pages3
    JournalExperimental Dermatology
    Volume27
    Issue number2
    DOIs
    Publication statusPublished - 2018 Feb 1

    Keywords

    • HSV1-tk
    • lentiviral vector
    • melanoma
    • small-animal PET/CT
    • [F]FDG
    • [F]FHBG

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Dermatology

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