Small conjugate-based theranostic agents: An encouraging approach for cancer therapy

Rajesh Kumar, Weon Sup Shin, Kyoung Sunwoo, Won Young Kim, Seyoung Koo, Sankarprasad Bhuniya, Jong Seung Kim

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

The advances in genomics, proteomics, and bioinformatics have directed the development of new anticancer agents to reduce drug abuse and increase safe and specific drug treatment. Theranostics, combining therapy and diagnosis, is an appealing approach for chemotherapy in medicine which exhibits improved biodistribution, selective cancer targeting ability, reduced toxicity, masked drug efficacy, and minimum side effects. The role of diagnosis tools in theranostics is to collect the information of the diseased state before and after specific treatment. Magnetic particle-, mesoporous silica-, various carbon allotrope-, and polymer nanoparticle-based theranostic systems are well accepted and clinically significant. Currently, small conjugate-based systems have received much attention for cancer treatment and diagnosis. The structural architecture of these systems is relatively simple, compact, biocompatible, and unidirectional. In this tutorial review, we summarize the latest developments on small conjugate based theranostic agents for tumor treatment and diagnosis using fluorescence and magnetic resonance imaging (MRI).

Original languageEnglish
Pages (from-to)6670-6683
Number of pages14
JournalChemical Society Reviews
Volume44
Issue number19
DOIs
Publication statusPublished - 2015 Oct 7

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Neoplasms
Drug therapy
Oncology
Chemotherapy
Magnetic resonance
Therapeutics
Bioinformatics
Aptitude
Silicon Dioxide
Pharmaceutical Preparations
Antineoplastic Agents
Medicine
Toxicity
Tumors
Polymers
Genomics
Computational Biology
Drug-Related Side Effects and Adverse Reactions
Carbon
Proteomics

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Small conjugate-based theranostic agents : An encouraging approach for cancer therapy. / Kumar, Rajesh; Shin, Weon Sup; Sunwoo, Kyoung; Kim, Won Young; Koo, Seyoung; Bhuniya, Sankarprasad; Kim, Jong Seung.

In: Chemical Society Reviews, Vol. 44, No. 19, 07.10.2015, p. 6670-6683.

Research output: Contribution to journalArticle

Kumar, R, Shin, WS, Sunwoo, K, Kim, WY, Koo, S, Bhuniya, S & Kim, JS 2015, 'Small conjugate-based theranostic agents: An encouraging approach for cancer therapy', Chemical Society Reviews, vol. 44, no. 19, pp. 6670-6683. https://doi.org/10.1039/c5cs00224a
Kumar, Rajesh ; Shin, Weon Sup ; Sunwoo, Kyoung ; Kim, Won Young ; Koo, Seyoung ; Bhuniya, Sankarprasad ; Kim, Jong Seung. / Small conjugate-based theranostic agents : An encouraging approach for cancer therapy. In: Chemical Society Reviews. 2015 ; Vol. 44, No. 19. pp. 6670-6683.
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