Small conjugate-based theranostic agents: An encouraging approach for cancer therapy

Rajesh Kumar, Weon Sup Shin, Kyoung Sunwoo, Won Young Kim, Seyoung Koo, Sankarprasad Bhuniya, Jong Seung Kim

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

The advances in genomics, proteomics, and bioinformatics have directed the development of new anticancer agents to reduce drug abuse and increase safe and specific drug treatment. Theranostics, combining therapy and diagnosis, is an appealing approach for chemotherapy in medicine which exhibits improved biodistribution, selective cancer targeting ability, reduced toxicity, masked drug efficacy, and minimum side effects. The role of diagnosis tools in theranostics is to collect the information of the diseased state before and after specific treatment. Magnetic particle-, mesoporous silica-, various carbon allotrope-, and polymer nanoparticle-based theranostic systems are well accepted and clinically significant. Currently, small conjugate-based systems have received much attention for cancer treatment and diagnosis. The structural architecture of these systems is relatively simple, compact, biocompatible, and unidirectional. In this tutorial review, we summarize the latest developments on small conjugate based theranostic agents for tumor treatment and diagnosis using fluorescence and magnetic resonance imaging (MRI).

Original languageEnglish
Pages (from-to)6670-6683
Number of pages14
JournalChemical Society Reviews
Volume44
Issue number19
DOIs
Publication statusPublished - 2015 Oct 7

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ASJC Scopus subject areas

  • Chemistry(all)

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