TY - JOUR
T1 - Small for gestational age and obesity
T2 - Epidemiology and general risks
AU - Nam, Hyo Kyoung
AU - Lee, Kee Hyoung
N1 - Publisher Copyright:
© 2018 Annals of Pediatric Endocrinology & Metabolism.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2018/3
Y1 - 2018/3
N2 - Children born small for gestational age (SGA) have several life-long consequences. Previous epidemiological studies investigated from childhood to adulthood reported that a number of chronic diseases originate in the prenatal period. With the emerging era of obesity epidemic, more concerns are related to being obese than being short-statured in SGA children. The exact mechanisms are uncertain; however, growth hormone-insulin-like growth factor axis disturbance by fetal programming and accelerated postnatal weight gain contributed to central adiposity in SGA children. In this review, we summarized the definitions and prevalence of SGA, epidemiology, and general risks of obesity in SGA children. Early interventions, before and after birth, are needed for healthy catch-up growth to prevent later obesity and related complications.
AB - Children born small for gestational age (SGA) have several life-long consequences. Previous epidemiological studies investigated from childhood to adulthood reported that a number of chronic diseases originate in the prenatal period. With the emerging era of obesity epidemic, more concerns are related to being obese than being short-statured in SGA children. The exact mechanisms are uncertain; however, growth hormone-insulin-like growth factor axis disturbance by fetal programming and accelerated postnatal weight gain contributed to central adiposity in SGA children. In this review, we summarized the definitions and prevalence of SGA, epidemiology, and general risks of obesity in SGA children. Early interventions, before and after birth, are needed for healthy catch-up growth to prevent later obesity and related complications.
KW - Epidemiology
KW - Obesity
KW - Small for gestational age
UR - http://www.scopus.com/inward/record.url?scp=85055618528&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055618528&partnerID=8YFLogxK
U2 - 10.6065/apem.2018.23.1.9
DO - 10.6065/apem.2018.23.1.9
M3 - Review article
AN - SCOPUS:85055618528
VL - 23
SP - 9
EP - 13
JO - Annals of Pediatric Endocrinology and Metabolism
JF - Annals of Pediatric Endocrinology and Metabolism
SN - 2287-1012
IS - 1
ER -