Small hepatocellular carcinoma: Ultrasonographic findings and histopathologic correlation

Kyeong Ah Kim, Won Jae Lee, Hyo Keun Lim, Cheol Min Park, Cheol Keun Park, In Ho Cha, Hae Young Seol

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


It is known that small hepatocellular carcinoma (HCCs) were usually hypoechoic at ultrasonography (US). In this study, we analyzed US findings of 42 small HCCs less than 2 cm in diameter and correlated them with histopathologic findings. US parameters were tumor size, tumor echogenecity, and morphologic features (peripheral halo, lateral shadow, posterior enhancement, and mosaic pattern), while histopathologic parameters were Edmonson grade and microscopic features (coagulation necrosis, interstitial fibrosis, fatty metamorphosis, sinusoidal dilatation, hemorrhage, encapsulation, and internal septation). One-third of HCCs was not hypoechoic. Tumor echogenecity and morphologic features were variable, regardless of tumor differentiation and microscopic features. In our study, it seemed that US detected histopathologic changes in small HCCs more frequently than previously known, but none of these US findings could suggest a specific histopathologic finding in small HCCs less than 2 cm in diameter.

Original languageEnglish
Pages (from-to)340-345
Number of pages6
JournalClinical Imaging
Issue number5
Publication statusPublished - 2003


  • Edmonson grade
  • HCCs
  • Mosaic pattern
  • Peripheral halo
  • Tumor echogenecity
  • Tumor size

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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