Small leucine zipper protein (sLZIP) negatively regulates skeletal muscle differentiation via interaction with α-actinin-4

Hyoung Tae An, Jeonghan Kim, Seungmin Yoo, Jesang Ko

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Cooperation between transcription factors and myogenic regulatory factors is important for skeletal muscle differentiation. Results: sLZIP inhibits expression of muscle-specific genes during myogenesis via disruption of an association betweenα-actinin- 4 and MEF2. Conclusion: A novel myogenesis regulatory mechanism of sLZIP is characterized. Significance: sLZIP can be used as a therapeutic target for treatment of muscle diseases.

Original languageEnglish
Pages (from-to)4969-4979
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number8
DOIs
Publication statusPublished - 2014 Feb 21

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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