Small-Molecule Two-Photon Probes for Bioimaging Applications

Hwan Myung Kim, Bong Rae Cho

Research output: Contribution to journalReview article

544 Citations (Scopus)


The scientific review presents a condensed, all-inclusive evaluation of the design, synthesis, and biomedical application of the various small-molecule two-photon (TP) probes that have been published before December 2014. The review has focused on only the TP probes for which the properties have been clearly characterized and which produce high-quality two-photon microscopy (TPM) images in an effort to avoid an excessive number of references. The review starts by describing the fundamental concept of two-photon absorption (TPA), followed by a description of the organic solvent-based model studies that established the use of TPM in the biomedical field.

Original languageEnglish
Pages (from-to)5014-5055
Number of pages42
JournalChemical reviews
Issue number11
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Chemistry(all)

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