Sodium butyrate suppresses interferon-gamma-, but not lipopolysaccharide- mediated induction of nitric oxide and tumor necrosis factor-alpha in microglia

Hee Sun Kim, So Young Whang, Moon Sook Woo, Jin Sun Park, Won-Ki Kim, Inn Oc Han

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

In the present study, we demonstrate that sodium butyrate repressed IFN-γ-induced expression of iNOS and TNF-α, but had little effect on LPS-induced expression in BV2 murine microglial cells. Sodium butyrate significantly inhibited NF-κB binding and NF-κB-mediated transcription induced by IFN-γ, suggesting that the anti-inflammatory effect of sodium butyrate is mediated via specific inhibition of the NF-κB pathway. IFN-γ is a major stimulator of innate and adaptive immune response. Thus, the specific down-regulation of IFN-γ-induced microglial activation by sodium butyrate may provide potential therapeutic strategies for a variety of inflammatory diseases in the central nervous system.

Original languageEnglish
Pages (from-to)85-93
Number of pages9
JournalJournal of Neuroimmunology
Volume151
Issue number1-2
DOIs
Publication statusPublished - 2004 Jun 1
Externally publishedYes

Fingerprint

Butyric Acid
Microglia
Interferon-gamma
Lipopolysaccharides
Nitric Oxide
Tumor Necrosis Factor-alpha
Central Nervous System Diseases
Adaptive Immunity
Innate Immunity
Anti-Inflammatory Agents
Down-Regulation
Therapeutics

Keywords

  • IFN-γ
  • iNOS
  • Microglia
  • NF-κB1
  • Sodium butyrate

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Sodium butyrate suppresses interferon-gamma-, but not lipopolysaccharide- mediated induction of nitric oxide and tumor necrosis factor-alpha in microglia. / Kim, Hee Sun; Whang, So Young; Woo, Moon Sook; Park, Jin Sun; Kim, Won-Ki; Han, Inn Oc.

In: Journal of Neuroimmunology, Vol. 151, No. 1-2, 01.06.2004, p. 85-93.

Research output: Contribution to journalArticle

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