Sodium-ion-selective two-photon fluorescent probe for in vivo imaging

Mi Kyung Kim, Chang Su Lim, Jong Tae Hong, Ji Hee Han, Hye Young Jang, Hwan Myung Kim, Bong-Rae Cho

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

"Chemical Equation Presented" Two photons are better than one: A two-photon probe (ANa1, see picture) shows strong twophoton fluorescence enhancement In response to Na + and a dissociation constant (K d l) of (26±2) mM in the cell. It can be easily loaded into the cells and can selectively detect intracellular free Na + in live cells and living tissues at a depth of 100-200 μm for a long period of time.

Original languageEnglish
Pages (from-to)364-367
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number2
DOIs
Publication statusPublished - 2010 Jan 8

Fingerprint

Fluorescent Dyes
Photons
Sodium
Ions
Imaging techniques
Fluorescence
Tissue

Keywords

  • Fluorescent probes
  • Live tissue
  • Sodium
  • Two-photon microscopy

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Sodium-ion-selective two-photon fluorescent probe for in vivo imaging. / Kim, Mi Kyung; Lim, Chang Su; Hong, Jong Tae; Han, Ji Hee; Jang, Hye Young; Kim, Hwan Myung; Cho, Bong-Rae.

In: Angewandte Chemie - International Edition, Vol. 49, No. 2, 08.01.2010, p. 364-367.

Research output: Contribution to journalArticle

Kim, Mi Kyung ; Lim, Chang Su ; Hong, Jong Tae ; Han, Ji Hee ; Jang, Hye Young ; Kim, Hwan Myung ; Cho, Bong-Rae. / Sodium-ion-selective two-photon fluorescent probe for in vivo imaging. In: Angewandte Chemie - International Edition. 2010 ; Vol. 49, No. 2. pp. 364-367.
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