Soft implantable microelectrodes for future medicine: Prosthetics, neural signal recording and neuromodulation

Joong Hoon Lee, Hanseop Kim, Jeong Hun Kim, Sang Hoon Lee

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

Implantable devices have provided various potential diagnostic options and therapeutic methods in diverse medical fields. A variety of hard-material-based implantable electrodes have been developed. However, several limitations for their chronic implantation remain, including mechanical mismatches at the interface between the electrode and the soft tissue, and biocompatibility. Soft-material-based implantable devices are suitable candidates for complementing the limitations of hard electrodes. Advances in microtechnology and materials science have largely solved many challenges, such as optimization of shape, minimization of infection, enhancement of biocompatibility and integration with components for diverse functions. Significant strides have also been made in mechanical matching of electrodes to soft tissue. In this review, we provide an overview of recent advances in soft-material-based implantable electrodes for medical applications, categorized according to their implantation site and material composition. We then review specific applications in three categories: neuroprosthetics, neural signal recording, and neuromodulation. Finally, we describe various strategies for the future development and application of implantable, soft-material-based devices.

Original languageEnglish
Pages (from-to)959-976
Number of pages18
JournalLab on a Chip - Miniaturisation for Chemistry and Biology
Volume16
Issue number6
DOIs
Publication statusPublished - 2016 Mar 21

Fingerprint

Microelectrodes
Prosthetics
Medicine
Electrodes
Implanted Electrodes
Equipment and Supplies
Microtechnology
Biocompatibility
Tissue
Medical applications
Materials science
Infection
Chemical analysis
Therapeutics

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Biochemistry
  • Biomedical Engineering

Cite this

Soft implantable microelectrodes for future medicine : Prosthetics, neural signal recording and neuromodulation. / Lee, Joong Hoon; Kim, Hanseop; Kim, Jeong Hun; Lee, Sang Hoon.

In: Lab on a Chip - Miniaturisation for Chemistry and Biology, Vol. 16, No. 6, 21.03.2016, p. 959-976.

Research output: Contribution to journalReview article

@article{1a519b55ad4d403a8d1f28280faccfaf,
title = "Soft implantable microelectrodes for future medicine: Prosthetics, neural signal recording and neuromodulation",
abstract = "Implantable devices have provided various potential diagnostic options and therapeutic methods in diverse medical fields. A variety of hard-material-based implantable electrodes have been developed. However, several limitations for their chronic implantation remain, including mechanical mismatches at the interface between the electrode and the soft tissue, and biocompatibility. Soft-material-based implantable devices are suitable candidates for complementing the limitations of hard electrodes. Advances in microtechnology and materials science have largely solved many challenges, such as optimization of shape, minimization of infection, enhancement of biocompatibility and integration with components for diverse functions. Significant strides have also been made in mechanical matching of electrodes to soft tissue. In this review, we provide an overview of recent advances in soft-material-based implantable electrodes for medical applications, categorized according to their implantation site and material composition. We then review specific applications in three categories: neuroprosthetics, neural signal recording, and neuromodulation. Finally, we describe various strategies for the future development and application of implantable, soft-material-based devices.",
author = "Lee, {Joong Hoon} and Hanseop Kim and Kim, {Jeong Hun} and Lee, {Sang Hoon}",
year = "2016",
month = "3",
day = "21",
doi = "10.1039/c5lc00842e",
language = "English",
volume = "16",
pages = "959--976",
journal = "Lab on a Chip - Miniaturisation for Chemistry and Biology",
issn = "1473-0197",
publisher = "Royal Society of Chemistry",
number = "6",

}

TY - JOUR

T1 - Soft implantable microelectrodes for future medicine

T2 - Prosthetics, neural signal recording and neuromodulation

AU - Lee, Joong Hoon

AU - Kim, Hanseop

AU - Kim, Jeong Hun

AU - Lee, Sang Hoon

PY - 2016/3/21

Y1 - 2016/3/21

N2 - Implantable devices have provided various potential diagnostic options and therapeutic methods in diverse medical fields. A variety of hard-material-based implantable electrodes have been developed. However, several limitations for their chronic implantation remain, including mechanical mismatches at the interface between the electrode and the soft tissue, and biocompatibility. Soft-material-based implantable devices are suitable candidates for complementing the limitations of hard electrodes. Advances in microtechnology and materials science have largely solved many challenges, such as optimization of shape, minimization of infection, enhancement of biocompatibility and integration with components for diverse functions. Significant strides have also been made in mechanical matching of electrodes to soft tissue. In this review, we provide an overview of recent advances in soft-material-based implantable electrodes for medical applications, categorized according to their implantation site and material composition. We then review specific applications in three categories: neuroprosthetics, neural signal recording, and neuromodulation. Finally, we describe various strategies for the future development and application of implantable, soft-material-based devices.

AB - Implantable devices have provided various potential diagnostic options and therapeutic methods in diverse medical fields. A variety of hard-material-based implantable electrodes have been developed. However, several limitations for their chronic implantation remain, including mechanical mismatches at the interface between the electrode and the soft tissue, and biocompatibility. Soft-material-based implantable devices are suitable candidates for complementing the limitations of hard electrodes. Advances in microtechnology and materials science have largely solved many challenges, such as optimization of shape, minimization of infection, enhancement of biocompatibility and integration with components for diverse functions. Significant strides have also been made in mechanical matching of electrodes to soft tissue. In this review, we provide an overview of recent advances in soft-material-based implantable electrodes for medical applications, categorized according to their implantation site and material composition. We then review specific applications in three categories: neuroprosthetics, neural signal recording, and neuromodulation. Finally, we describe various strategies for the future development and application of implantable, soft-material-based devices.

UR - http://www.scopus.com/inward/record.url?scp=84960424222&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960424222&partnerID=8YFLogxK

U2 - 10.1039/c5lc00842e

DO - 10.1039/c5lc00842e

M3 - Review article

C2 - 26891410

AN - SCOPUS:84960424222

VL - 16

SP - 959

EP - 976

JO - Lab on a Chip - Miniaturisation for Chemistry and Biology

JF - Lab on a Chip - Miniaturisation for Chemistry and Biology

SN - 1473-0197

IS - 6

ER -