Soft-split sparse regression based random forest for predicting future clinical scores of Alzheimer’s disease

Lei Huang, Yaozong Gao, Yan Jin, Kim Han Thung, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

In this study, we propose a novel sparse regression based random forest (RF) to predict future clinical scores of Alzheimer’s disease (AD) with the baseline scores and the MRI features. To avoid the stair-like decision boundary caused by axis-aligned split function in the conventional RF, we present a supervised method to construct the oblique split function by using sparse regression to select the informative features and transform the original features into the target-like features that are more discriminative. Then, we construct the oblique splitting function by applying the principal component analysis (PCA) on the transformed target-like features. Furthermore, to reduce the negative impact of potential missplit induced by the conventional “hard-split”, we further introduce the “soft-split” technique, in which both left and right nodes are visited with certain weights given a test sample. The experiment results show that sparse regression based RF alone can improve the prediction performance of the conventional RF. And further improvement can be achieved when both of the techniques are combined.

Original languageEnglish
Title of host publicationMachine Learning in Medical Imaging - 6th International Workshop, MLMI 2015 Held in Conjunction with MICCAI 2015, Proceedings
EditorsLuping Zhou, Yinghuan Shi, Li Wang, Qian Wang
PublisherSpringer Verlag
Pages246-254
Number of pages9
ISBN (Print)9783319248875
DOIs
Publication statusPublished - 2015
Event6th International Workshop on Machine Learning in Medical Imaging, MLMI 2015 and Held in Conjunction with 18th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2015 - Munich, Germany
Duration: 2015 Oct 52015 Oct 5

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9352
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other6th International Workshop on Machine Learning in Medical Imaging, MLMI 2015 and Held in Conjunction with 18th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2015
CountryGermany
CityMunich
Period15/10/515/10/5

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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  • Cite this

    Huang, L., Gao, Y., Jin, Y., Thung, K. H., & Shen, D. (2015). Soft-split sparse regression based random forest for predicting future clinical scores of Alzheimer’s disease. In L. Zhou, Y. Shi, L. Wang, & Q. Wang (Eds.), Machine Learning in Medical Imaging - 6th International Workshop, MLMI 2015 Held in Conjunction with MICCAI 2015, Proceedings (pp. 246-254). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 9352). Springer Verlag. https://doi.org/10.1007/978-3-319-24888-2_30