Sol-gel derived nanoscale bioactive glass (NBG) particles reinforced poly(ε-caprolactone) composites for bone tissue engineering

Bo Lei, Kwan Ha Shin, Da Young Noh, In Hwan Jo, Young-Hag Koh, Hyoun Ee Kim, Sung Eun Kim

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

This study investigated the effect of the addition of sol-gel derived nanoscale bioactive glass (NBG) particles on the mechanical properties and biological performances of PCL polymer, in order to evaluate the potential applications of PCL/NBG composites for bone tissue regeneration. Regardless of the NBG contents (10, 20, and 30 wt.%), the NBG particles, which were synthesized through the sol-gel process using polyethylene glycol (PEG) polymer as a template, could be uniformly dispersed in the PCL matrix, while generating pores in the PCL/NBG composites. The elastic modulus of the PCL/NBG composites increased remarkably from 89 ± 11 MPa to 383 ± 50 MPa with increasing NBG content from 0 to 30 wt.%, while still showing good ultimate tensile strength in the range of 15-19 MPa. The hydrophilicity, water absorption and degradation behavior of the PCL/NBG composites were also enhanced by the addition of the NBG particles. Furthermore, the PCL/NBG composite with a NBG content of 30 wt.% showed significantly enhanced in vitro bioactivity and cellular response compared to those of the pure PCL.

Original languageEnglish
Pages (from-to)1102-1108
Number of pages7
JournalMaterials Science and Engineering C
Volume33
Issue number3
DOIs
Publication statusPublished - 2013 Apr 1

    Fingerprint

Keywords

  • Bioactive glass
  • Biodegradation
  • Composite
  • Hard tissue
  • Mechanical properties
  • Polymer

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials
  • Medicine(all)

Cite this