Sol-gel derived nanoscale bioactive glass (NBG) particles reinforced poly(ε-caprolactone) composites for bone tissue engineering

Bo Lei, Kwan Ha Shin, Da Young Noh, In Hwan Jo, Young-Hag Koh, Hyoun Ee Kim, Sung Eun Kim

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

This study investigated the effect of the addition of sol-gel derived nanoscale bioactive glass (NBG) particles on the mechanical properties and biological performances of PCL polymer, in order to evaluate the potential applications of PCL/NBG composites for bone tissue regeneration. Regardless of the NBG contents (10, 20, and 30 wt.%), the NBG particles, which were synthesized through the sol-gel process using polyethylene glycol (PEG) polymer as a template, could be uniformly dispersed in the PCL matrix, while generating pores in the PCL/NBG composites. The elastic modulus of the PCL/NBG composites increased remarkably from 89 ± 11 MPa to 383 ± 50 MPa with increasing NBG content from 0 to 30 wt.%, while still showing good ultimate tensile strength in the range of 15-19 MPa. The hydrophilicity, water absorption and degradation behavior of the PCL/NBG composites were also enhanced by the addition of the NBG particles. Furthermore, the PCL/NBG composite with a NBG content of 30 wt.% showed significantly enhanced in vitro bioactivity and cellular response compared to those of the pure PCL.

Original languageEnglish
Pages (from-to)1102-1108
Number of pages7
JournalMaterials Science and Engineering C
Volume33
Issue number3
DOIs
Publication statusPublished - 2013 Apr 1

Fingerprint

Bioactive glass
tissue engineering
Polymethyl Methacrylate
Tissue Engineering
activity (biology)
Tissue engineering
bones
Particles (particulate matter)
Sol-gels
Glass
Bone
Gels
gels
Bone and Bones
composite materials
glass
Composite materials
Polymers
polycaprolactone
Tissue regeneration

Keywords

  • Bioactive glass
  • Biodegradation
  • Composite
  • Hard tissue
  • Mechanical properties
  • Polymer

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials
  • Medicine(all)

Cite this

Sol-gel derived nanoscale bioactive glass (NBG) particles reinforced poly(ε-caprolactone) composites for bone tissue engineering. / Lei, Bo; Shin, Kwan Ha; Noh, Da Young; Jo, In Hwan; Koh, Young-Hag; Kim, Hyoun Ee; Kim, Sung Eun.

In: Materials Science and Engineering C, Vol. 33, No. 3, 01.04.2013, p. 1102-1108.

Research output: Contribution to journalArticle

Lei, Bo ; Shin, Kwan Ha ; Noh, Da Young ; Jo, In Hwan ; Koh, Young-Hag ; Kim, Hyoun Ee ; Kim, Sung Eun. / Sol-gel derived nanoscale bioactive glass (NBG) particles reinforced poly(ε-caprolactone) composites for bone tissue engineering. In: Materials Science and Engineering C. 2013 ; Vol. 33, No. 3. pp. 1102-1108.
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