Sol-gel preparation and properties of fluoride-substituted hydroxyapatite powders

Hae W. Kim, Long H. Li, Young-Hag Koh, Jonathan C. Knowles, Hyoun E. Kim

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Hydroxyapatite (HA) and fluor-hydroxyapatite (FHA) powders were synthesized by a sol-gel method for usage as bone filler and drug carrier. Calcium nitrate and triethyl phosphite were used as precursors under an ethanol-water-based solution. Different amounts of ammonium fluoride (NH4F) were incorporated for the preparation of FHA powders. With heat treatment above 400°C, a characteristic apatite phase was observed for all the sol-gel powders. However, the crystallization temperature decreased with increasing fluoride addition. The tricalcium phosphate (TCP) phase formed in the pure HA powder above 800°C was attenuated in the FHA powders, confirming an enhanced phase stability of the FHA powders. Increasing the F- addition improved crystallinity and increased the crystallite size, as was determined from X-ray diffraction (XRD) analyses. The lattice parameters of the heat-treated powders varied corresponding to the fluoride addition, i.e., a gradual decrease in the a-axis, while little change in the c-axis was observed with increasing fluoride addition, indicating a nearly complete substitution of fluoride within the apatite lattice. However, little difference was observed with heat-treatment temperatures (400°-1000°C). The powders substituted with fluoride exhibited reduced dissolution rates in an in vitro solution as compared with the pure HA powder, suggesting the possibility of tailoring bioactivity with fluoride substitution.

Original languageEnglish
Pages (from-to)1939-1944
Number of pages6
JournalJournal of the American Ceramic Society
Volume87
Issue number10
Publication statusPublished - 2004 Oct 1
Externally publishedYes

Fingerprint

Durapatite
Fluorides
Hydroxyapatite
fluoride
Powders
Sol-gels
gel
Apatites
apatite
Apatite
substitution
Substitution reactions
bioactivity
Heat treatment
crystallinity
Drug Carriers
Phase stability
bone
ethanol
Crystallite size

ASJC Scopus subject areas

  • Ceramics and Composites

Cite this

Sol-gel preparation and properties of fluoride-substituted hydroxyapatite powders. / Kim, Hae W.; Li, Long H.; Koh, Young-Hag; Knowles, Jonathan C.; Kim, Hyoun E.

In: Journal of the American Ceramic Society, Vol. 87, No. 10, 01.10.2004, p. 1939-1944.

Research output: Contribution to journalArticle

Kim, Hae W. ; Li, Long H. ; Koh, Young-Hag ; Knowles, Jonathan C. ; Kim, Hyoun E. / Sol-gel preparation and properties of fluoride-substituted hydroxyapatite powders. In: Journal of the American Ceramic Society. 2004 ; Vol. 87, No. 10. pp. 1939-1944.
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