Abstract
The aim of this study was to develop and investigate thermoresponsive hydrogel incorporating curcumin (Cur) for application as a transdermal delivery system. Cur was encapsulated within solid lipid nanoparticles via ultrasonic homogenization, and these were introduced into a thermoresponsive hydrogel composed of pluronic F68 (PF68) and F127 (PF127). The hydrogel composed of PF68 and PF127 in 10:90 ratio transformed from sol to gel at 29.3 °C close to skin temperature. The skin adhesiveness and adhesive strength of the hydrogel with 0.2% (w/w) of XG was 1.64 and 1.24 times higher than those of the hydrogel without XG, respectively. The physiochemical characteristics of prepared formulations were investigated via observation of particle size, polydispersity index, transmission electron microscopy, and scanning electron microscopy. Moreover, Fourier transform infrared spectroscopy analysis was performed at physiological temperature, which revealed lower hydrogen bonding intensity at gel phase than at sol phase. The cumulative amount of Cur that penetrated significantly increased compared with the Cur ethanol solution.
| Original language | English |
|---|---|
| Article number | 46004 |
| Journal | Journal of Applied Polymer Science |
| Volume | 135 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2018 Mar 15 |
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Keywords
- drug delivery systems
- gels
- nanoparticles
- nanowires and nanocrystals
- rheology
- stimuli-sensitive polymers
ASJC Scopus subject areas
- Chemistry(all)
- Surfaces, Coatings and Films
- Polymers and Plastics
- Materials Chemistry
Cite this
Solid lipid nanoparticles loaded thermoresponsive pluronic–xanthan gum hydrogel as a transdermal delivery system. / Lee, Min Hyeock; Shin, Gye Hwa; Park, Hyun Jin.
In: Journal of Applied Polymer Science, Vol. 135, No. 11, 46004, 15.03.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Solid lipid nanoparticles loaded thermoresponsive pluronic–xanthan gum hydrogel as a transdermal delivery system
AU - Lee, Min Hyeock
AU - Shin, Gye Hwa
AU - Park, Hyun Jin
PY - 2018/3/15
Y1 - 2018/3/15
N2 - The aim of this study was to develop and investigate thermoresponsive hydrogel incorporating curcumin (Cur) for application as a transdermal delivery system. Cur was encapsulated within solid lipid nanoparticles via ultrasonic homogenization, and these were introduced into a thermoresponsive hydrogel composed of pluronic F68 (PF68) and F127 (PF127). The hydrogel composed of PF68 and PF127 in 10:90 ratio transformed from sol to gel at 29.3 °C close to skin temperature. The skin adhesiveness and adhesive strength of the hydrogel with 0.2% (w/w) of XG was 1.64 and 1.24 times higher than those of the hydrogel without XG, respectively. The physiochemical characteristics of prepared formulations were investigated via observation of particle size, polydispersity index, transmission electron microscopy, and scanning electron microscopy. Moreover, Fourier transform infrared spectroscopy analysis was performed at physiological temperature, which revealed lower hydrogen bonding intensity at gel phase than at sol phase. The cumulative amount of Cur that penetrated significantly increased compared with the Cur ethanol solution.
AB - The aim of this study was to develop and investigate thermoresponsive hydrogel incorporating curcumin (Cur) for application as a transdermal delivery system. Cur was encapsulated within solid lipid nanoparticles via ultrasonic homogenization, and these were introduced into a thermoresponsive hydrogel composed of pluronic F68 (PF68) and F127 (PF127). The hydrogel composed of PF68 and PF127 in 10:90 ratio transformed from sol to gel at 29.3 °C close to skin temperature. The skin adhesiveness and adhesive strength of the hydrogel with 0.2% (w/w) of XG was 1.64 and 1.24 times higher than those of the hydrogel without XG, respectively. The physiochemical characteristics of prepared formulations were investigated via observation of particle size, polydispersity index, transmission electron microscopy, and scanning electron microscopy. Moreover, Fourier transform infrared spectroscopy analysis was performed at physiological temperature, which revealed lower hydrogen bonding intensity at gel phase than at sol phase. The cumulative amount of Cur that penetrated significantly increased compared with the Cur ethanol solution.
KW - drug delivery systems
KW - gels
KW - nanoparticles
KW - nanowires and nanocrystals
KW - rheology
KW - stimuli-sensitive polymers
UR - http://www.scopus.com/inward/record.url?scp=85034232291&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85034232291&partnerID=8YFLogxK
U2 - 10.1002/app.46004
DO - 10.1002/app.46004
M3 - Article
AN - SCOPUS:85034232291
VL - 135
JO - Journal of Applied Polymer Science
JF - Journal of Applied Polymer Science
SN - 0021-8995
IS - 11
M1 - 46004
ER -