Solid-phase synthesis of styryl dyes and their application as amyloid sensors

Qian Li, Jun Seok Lee, Chanki Ha, Beum Park Chan, Guang Yang, Biao Gan Wen, Young Tae Chang

Research output: Contribution to journalArticlepeer-review

116 Citations (Scopus)

Abstract

The combinatorial approach: A library of fluorescent styryl dyes (320 compounds) was prepared by solid-phase chemistry. The dyes were screened for their detection of amyloid aggregates, which are associated with diseases such as Alzheimer's, and two of the 320 compounds screened, 2C40 and 2E10, showed promise as brain-imaging agents (see microscopy image). (Chemical equation presented).

Original languageEnglish
Pages (from-to)6331-6335
Number of pages5
JournalAngewandte Chemie - International Edition
Volume43
Issue number46
DOIs
Publication statusPublished - 2004 Nov 26
Externally publishedYes

Keywords

  • Combinatorial chemistry
  • Dyes/pigments
  • Fluorescent probes
  • Imaging agents
  • Solid-phase synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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