Some membrane property changes following axotomy in Aδ-type DRG cells are related to cold allodynia in rat

Yang In Kim, S. H. Kim, E. J. Oh, B. Sung, Heung Sik Na, Hee Chul Han, Young Wook Yoon, S. K. Hong

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Numerous studies have suggested that changes in electrophysiological properties of primary sensory neurons after axonal injury contribute to the generation of neuropathic pain. Presently, however, it is unclear which of the changes is important. To address this issue, we performed behavioral and electrophysiological experiments in a double-blind fashion; we made intracellular recordings in the S1 dorsal root ganglia excised from rats exhibiting cold allodynia behavior after chronic S1 spinal nerve transaction (allodynia-positive group) and from rats lacking such behavior after the same nerve injury (allodynia-negative group) or sham injury (sham group). In this study, we sought which of the membrane property changes produced by the spinal nerve injury in each of C-, Aδ- and Aα/β-cell populations was unique to the allodynia-positive group. Analyses of our data revealed that only some changes in Aδ-cells (e.g. the decrease in resting membrane potential and in the threshold of central process) were more pronounced in or unique to the allodynia-positive group. We concluded that certain membrane property changes in the somata and dorsal root axons of Aδ-cells might be important in the generation of cold allodynia.

Original languageEnglish
Pages (from-to)1493-1499
Number of pages7
JournalNeuroReport
Volume10
Issue number7
Publication statusPublished - 1999 May 14

Fingerprint

Axotomy
Diagnosis-Related Groups
Hyperalgesia
Membranes
Spinal Nerves
Wounds and Injuries
Spinal Injuries
Spinal Nerve Roots
Spinal Ganglia
Carisoprodol
Neuralgia
Sensory Receptor Cells
Membrane Potentials
Axons
Population

Keywords

  • Allodynia
  • Axotomy
  • Dorsal root
  • DRG
  • Electrophysiology
  • Neuropathy
  • Pain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Some membrane property changes following axotomy in Aδ-type DRG cells are related to cold allodynia in rat. / Kim, Yang In; Kim, S. H.; Oh, E. J.; Sung, B.; Na, Heung Sik; Han, Hee Chul; Yoon, Young Wook; Hong, S. K.

In: NeuroReport, Vol. 10, No. 7, 14.05.1999, p. 1493-1499.

Research output: Contribution to journalArticle

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