Sonographic Evaluation of Breast Nodules: Comparison of Conventional, Real-Time Compound, and Pulse-Inversion Harmonic Images

Bo Kyoung Seo, Yu Whan Oh, Hyung Rae Kim, Hong Weon Kim, Chang Ho Kang, Nam Joon Lee, Jung Hyuk Kim, Bum Jin Park, Kyu Ran Cho, June Young Lee, Ki Yeoul Lee, Jeoung Won Bae

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)


    Objective: To compare the use of conventional, real-time compound, and pulse-inversion harmonic imaging in the evaluation of breast nodules. Materials and Methods: Fifty-two breast nodules were included in this study, conducted between May and December 2000, in which conventional, real-time compound, and pulse-inversion harmonic images were obtained in the same plane. Three radiologists, each blinded to the interpretations of the other two, evaluated the findings, characterizing the lesions and ranking the three techniques from grade 1, the worst, to grade 3, the best. Lesion conspicuity was assessed, and lesions were also characterized in terms of their margin, clarity of internal echotexture, and clarity of posterior echo pattern. The three techniques were compared using Friedman's test, and interobserver agreement in image interpretation was assessed by means of the intraclass correlation coefficient. Results: With regard to lesion conspicuity, margin, and internal echotexture of the nodules, real-time compound imaging was the best technique (p<0.05); in terms of posterior echo pattern, the best was pulse-inversion harmonic imaging (p<0.05). Real-time compound and pulse inversion harmonic imaging were better than conventional sonography in all evaluative aspects. Interobserver agreement was greater than moderate. Conclusion: Real-time compound and pulse-inversion harmonic imaging procedures are superior to conventional sonography in terms of both lesion conspicuity and the further characterization of breast nodules. Real-time compound imaging is the best technique for evaluation of the margin and internal echotexture of nodules, while pulse-inversion harmonic imaging is very effective for the evaluation of the posterior echo patterns.

    Original languageEnglish
    Pages (from-to)38-44
    Number of pages7
    JournalKorean journal of radiology
    Issue number1
    Publication statusPublished - 2002


    • Breast, US
    • Ultrasound (US)
    • Ultrasound (US), comparative studies
    • Ultrasound (US), technology

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging


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