Source, biosynthesis, biological activities and pharmacokinetics of oxyresveratrol

Young Hee Lim, Ki Hyun Kim, Jeong Keun Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Oxyresveratrol (trans-2,3',4,5'-tetrahydroxystilbene) has been receiving increasing attention because of its astonishing biological activities, including antihyperlipidemic, neuroprotection, antidiabetic, anticancer, antiinflammation, immunomodulation, antiaging, and antioxidant activities. Oxyresveratrol is a stilbenoid, a type of natural phenol and a phytoalexin produced in the roots, stems, leaves, and fruits of several plants. It was first isolated from the heartwood of Artocarpus lakoocha, and has also been found in various plants, including Smilax China, Morus alba, Varatrum nigrum, Scirpus maritinus, and Maclura pomifera. Oxyresveratrol, an aglycone of mulberroside A, has been produced by microbial biotransformation or enzymatic hydrolysis of a glycosylated stilbene mulberroside A, which is one of the major compounds of the roots of M. alba. Oxyresveratrol shows less cytotoxicity, better antioxidant activity and polarity, and higher cell permeability and bioavailability than resveratrol (trans-3,5,4'-trihydroxystilbene), a well-known antioxidant, suggesting that oxyresveratrol might be a potential candidate for use in health functional food and medicine. This review focuses on the plant sources, chemical characteristics, analysis, biosynthesis, and biological activities of oxyresveratrol as well as describes the perspectives on further exploration of oxyresveratrol.

Original languageEnglish
Pages (from-to)545-555
Number of pages11
JournalKorean Journal of Food Science and Technology
Volume47
Issue number5
DOIs
Publication statusPublished - 2015 Oct 1

Fingerprint

pharmacokinetics
bioactive properties
Morus alba
Pharmacokinetics
biosynthesis
Artocarpus lacucha
Maclura pomifera
antioxidant activity
stilbenoids
hypoglycemic agents
Scirpus
immunomodulation
health foods
stilbenes
phytoalexins
resveratrol
heartwood
enzymatic hydrolysis
biotransformation
Antioxidants

Keywords

  • Biological Activity
  • Biosynthesis
  • Oxyresveratrol
  • Pharmacokinetics
  • Stilbenoid

ASJC Scopus subject areas

  • Food Science
  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Source, biosynthesis, biological activities and pharmacokinetics of oxyresveratrol. / Lim, Young Hee; Kim, Ki Hyun; Kim, Jeong Keun.

In: Korean Journal of Food Science and Technology, Vol. 47, No. 5, 01.10.2015, p. 545-555.

Research output: Contribution to journalArticle

@article{429703452190409e8e2bfc4a9eda0c91,
title = "Source, biosynthesis, biological activities and pharmacokinetics of oxyresveratrol",
abstract = "Oxyresveratrol (trans-2,3',4,5'-tetrahydroxystilbene) has been receiving increasing attention because of its astonishing biological activities, including antihyperlipidemic, neuroprotection, antidiabetic, anticancer, antiinflammation, immunomodulation, antiaging, and antioxidant activities. Oxyresveratrol is a stilbenoid, a type of natural phenol and a phytoalexin produced in the roots, stems, leaves, and fruits of several plants. It was first isolated from the heartwood of Artocarpus lakoocha, and has also been found in various plants, including Smilax China, Morus alba, Varatrum nigrum, Scirpus maritinus, and Maclura pomifera. Oxyresveratrol, an aglycone of mulberroside A, has been produced by microbial biotransformation or enzymatic hydrolysis of a glycosylated stilbene mulberroside A, which is one of the major compounds of the roots of M. alba. Oxyresveratrol shows less cytotoxicity, better antioxidant activity and polarity, and higher cell permeability and bioavailability than resveratrol (trans-3,5,4'-trihydroxystilbene), a well-known antioxidant, suggesting that oxyresveratrol might be a potential candidate for use in health functional food and medicine. This review focuses on the plant sources, chemical characteristics, analysis, biosynthesis, and biological activities of oxyresveratrol as well as describes the perspectives on further exploration of oxyresveratrol.",
keywords = "Biological Activity, Biosynthesis, Oxyresveratrol, Pharmacokinetics, Stilbenoid",
author = "Lim, {Young Hee} and Kim, {Ki Hyun} and Kim, {Jeong Keun}",
year = "2015",
month = "10",
day = "1",
doi = "10.9721/KJFST.2015.47.5.545",
language = "English",
volume = "47",
pages = "545--555",
journal = "Korean Journal of Food Science and Technology",
issn = "0367-6293",
publisher = "Tong Kwahak Hoe",
number = "5",

}

TY - JOUR

T1 - Source, biosynthesis, biological activities and pharmacokinetics of oxyresveratrol

AU - Lim, Young Hee

AU - Kim, Ki Hyun

AU - Kim, Jeong Keun

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Oxyresveratrol (trans-2,3',4,5'-tetrahydroxystilbene) has been receiving increasing attention because of its astonishing biological activities, including antihyperlipidemic, neuroprotection, antidiabetic, anticancer, antiinflammation, immunomodulation, antiaging, and antioxidant activities. Oxyresveratrol is a stilbenoid, a type of natural phenol and a phytoalexin produced in the roots, stems, leaves, and fruits of several plants. It was first isolated from the heartwood of Artocarpus lakoocha, and has also been found in various plants, including Smilax China, Morus alba, Varatrum nigrum, Scirpus maritinus, and Maclura pomifera. Oxyresveratrol, an aglycone of mulberroside A, has been produced by microbial biotransformation or enzymatic hydrolysis of a glycosylated stilbene mulberroside A, which is one of the major compounds of the roots of M. alba. Oxyresveratrol shows less cytotoxicity, better antioxidant activity and polarity, and higher cell permeability and bioavailability than resveratrol (trans-3,5,4'-trihydroxystilbene), a well-known antioxidant, suggesting that oxyresveratrol might be a potential candidate for use in health functional food and medicine. This review focuses on the plant sources, chemical characteristics, analysis, biosynthesis, and biological activities of oxyresveratrol as well as describes the perspectives on further exploration of oxyresveratrol.

AB - Oxyresveratrol (trans-2,3',4,5'-tetrahydroxystilbene) has been receiving increasing attention because of its astonishing biological activities, including antihyperlipidemic, neuroprotection, antidiabetic, anticancer, antiinflammation, immunomodulation, antiaging, and antioxidant activities. Oxyresveratrol is a stilbenoid, a type of natural phenol and a phytoalexin produced in the roots, stems, leaves, and fruits of several plants. It was first isolated from the heartwood of Artocarpus lakoocha, and has also been found in various plants, including Smilax China, Morus alba, Varatrum nigrum, Scirpus maritinus, and Maclura pomifera. Oxyresveratrol, an aglycone of mulberroside A, has been produced by microbial biotransformation or enzymatic hydrolysis of a glycosylated stilbene mulberroside A, which is one of the major compounds of the roots of M. alba. Oxyresveratrol shows less cytotoxicity, better antioxidant activity and polarity, and higher cell permeability and bioavailability than resveratrol (trans-3,5,4'-trihydroxystilbene), a well-known antioxidant, suggesting that oxyresveratrol might be a potential candidate for use in health functional food and medicine. This review focuses on the plant sources, chemical characteristics, analysis, biosynthesis, and biological activities of oxyresveratrol as well as describes the perspectives on further exploration of oxyresveratrol.

KW - Biological Activity

KW - Biosynthesis

KW - Oxyresveratrol

KW - Pharmacokinetics

KW - Stilbenoid

UR - http://www.scopus.com/inward/record.url?scp=84950262048&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84950262048&partnerID=8YFLogxK

U2 - 10.9721/KJFST.2015.47.5.545

DO - 10.9721/KJFST.2015.47.5.545

M3 - Article

AN - SCOPUS:84950262048

VL - 47

SP - 545

EP - 555

JO - Korean Journal of Food Science and Technology

JF - Korean Journal of Food Science and Technology

SN - 0367-6293

IS - 5

ER -