Sources of Polycyclic Aromatic Hydrocarbon Exposure in Non-Occupationally Exposed Koreans

Mihi Yang, Soyeon Kim, Eun Il Lee, Hae Kwan Cheong, Seong Sil Chang, Daehee Kang, Yunhee Choi, Su Man Lee, Jae Yeon Jang

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Urinary 1-hydroxypyrene (1-OHP), an exposure biomarker for polycyclic aromatic hydrocarbons (PAHs), was used to identify potential sources of PAH exposure for 660 Koreans who were not occupationally exposed to PAHs (65% male; 35% female; mean age, 36.5 ± 11.1 years). In this study, 74% of subjects had detectable levels of urinary 1-OHP, with a concentration range of 0.001-3.796 μg/L (median, 0.079 μg/L). A backward elimination was conducted: five variables were selected with a significance level for removal of P ≤ 0.1. The results of this study showed that residence in areas with relatively poor environmental conditions (Seoul and Suwon) was strongly associated with high concentrations of urinary 1-OHP (P = 0.007), while consumption of fried chicken and length of time spent outdoors had marginal positive associations with urinary 1-OHP levels (P = 0.06 and P = 0.09, respectively). Compared with the above three factors, tobacco smoking and urinary cotinine levels were poorly associated with urinary 1-OHP (P = 0.16 and 0.23, respectively). Pear consumption had an inverse association with urinary 1-OHP levels (P < 0.01). Individual variations in urinary 1-OHP concentrations were evaluated by considering the subjects' age, sex, and genetic polymorphisms in enzymes involved in the metabolism of PAHs. Among the individual variations, GSTT1-present subjects showed higher 1-OHP levels than GSTT1-absent subjects in cities having 10-μm particulate matter (PM 10) levels and population density lower than those of Seoul and Suwon (P < 0.05). These epidemiological results suggest that the above factors that should be considered in preventing PAH exposure.

Original languageEnglish
Pages (from-to)250-257
Number of pages8
JournalEnvironmental and Molecular Mutagenesis
Volume42
Issue number4
DOIs
Publication statusPublished - 2003 Dec 1

Fingerprint

Polycyclic Aromatic Hydrocarbons
PAH
individual variation
Cotinine
Pyrus
Particulate Matter
Tobacco
Biomarkers
Genetic Polymorphisms
Population Density
smoking
Polymorphism
tobacco
Metabolism
biomarker
particulate matter
Chickens
population density
polymorphism
metabolism

Keywords

  • 1-hydroxypyrene
  • Biomarker
  • Exposure route
  • Genetic polymorphism
  • Polycyclic aromatic hydrocarbons

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Genetics
  • Genetics(clinical)
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Sources of Polycyclic Aromatic Hydrocarbon Exposure in Non-Occupationally Exposed Koreans. / Yang, Mihi; Kim, Soyeon; Lee, Eun Il; Cheong, Hae Kwan; Chang, Seong Sil; Kang, Daehee; Choi, Yunhee; Lee, Su Man; Jang, Jae Yeon.

In: Environmental and Molecular Mutagenesis, Vol. 42, No. 4, 01.12.2003, p. 250-257.

Research output: Contribution to journalArticle

Yang, M, Kim, S, Lee, EI, Cheong, HK, Chang, SS, Kang, D, Choi, Y, Lee, SM & Jang, JY 2003, 'Sources of Polycyclic Aromatic Hydrocarbon Exposure in Non-Occupationally Exposed Koreans', Environmental and Molecular Mutagenesis, vol. 42, no. 4, pp. 250-257. https://doi.org/10.1002/em.10196
Yang, Mihi ; Kim, Soyeon ; Lee, Eun Il ; Cheong, Hae Kwan ; Chang, Seong Sil ; Kang, Daehee ; Choi, Yunhee ; Lee, Su Man ; Jang, Jae Yeon. / Sources of Polycyclic Aromatic Hydrocarbon Exposure in Non-Occupationally Exposed Koreans. In: Environmental and Molecular Mutagenesis. 2003 ; Vol. 42, No. 4. pp. 250-257.
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