Spatial distribution and longitudinal development of deep cortical sulcal landmarks in infants

Yu Meng, Gang Li, Weili Lin, John H. Gilmore, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Sulcal pits, the locally deepest points in sulci of the cerebral cortex, are found to be spatially highly consistent across human adult individuals. It is suggested that sulcal pits are genetically controlled and have close relationships with functional areas. To date, most imaging studies of sulcal pits are focused on adult brains, yet little is known about the spatial distribution and temporal development of sulcal pits in the first 2 years of life, the most dynamic period of postnatal brain development. Studying sulcal pits during this period would enrich our current limited understanding of the developmental trajectories of sulcal pits and provide insights into neurodevelopmental disorders associated with abnormal cortical foldings. In this paper, by using surface-based morphometry, for the first time, we systemically investigated the spatial distribution and temporal development of sulcal pits in major sulci from 73 healthy infants, each with longitudinal 3T MR scans at term birth, 1 year, and 2 years of age. Our results suggest that the consistency of spatial distribution of sulcal pits in major sulci across subjects has already existed at term birth and this spatial distribution pattern is relatively stable during cortex development in the first 2 years, despite that the cortex expands dramatically and the sulcal depth increases considerably.

Original languageEnglish
Title of host publication2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1214-1217
Number of pages4
ISBN (Print)9781467319591
Publication statusPublished - 2014 Jul 29
Externally publishedYes
Event2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 - Beijing, China
Duration: 2014 Apr 292014 May 2

Other

Other2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014
CountryChina
CityBeijing
Period14/4/2914/5/2

Fingerprint

Term Birth
Spatial distribution
Brain
Cerebral Cortex
Trajectories
Imaging techniques
Neurodevelopmental Disorders

Keywords

  • Cortical surface
  • Infant
  • Longitudinal development
  • Sulcal depth
  • Sulcal pits

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Meng, Y., Li, G., Lin, W., Gilmore, J. H., & Shen, D. (2014). Spatial distribution and longitudinal development of deep cortical sulcal landmarks in infants. In 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 (pp. 1214-1217). [6868094] Institute of Electrical and Electronics Engineers Inc..

Spatial distribution and longitudinal development of deep cortical sulcal landmarks in infants. / Meng, Yu; Li, Gang; Lin, Weili; Gilmore, John H.; Shen, Dinggang.

2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014. Institute of Electrical and Electronics Engineers Inc., 2014. p. 1214-1217 6868094.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Meng, Y, Li, G, Lin, W, Gilmore, JH & Shen, D 2014, Spatial distribution and longitudinal development of deep cortical sulcal landmarks in infants. in 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014., 6868094, Institute of Electrical and Electronics Engineers Inc., pp. 1214-1217, 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014, Beijing, China, 14/4/29.
Meng Y, Li G, Lin W, Gilmore JH, Shen D. Spatial distribution and longitudinal development of deep cortical sulcal landmarks in infants. In 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014. Institute of Electrical and Electronics Engineers Inc. 2014. p. 1214-1217. 6868094
Meng, Yu ; Li, Gang ; Lin, Weili ; Gilmore, John H. ; Shen, Dinggang. / Spatial distribution and longitudinal development of deep cortical sulcal landmarks in infants. 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014. Institute of Electrical and Electronics Engineers Inc., 2014. pp. 1214-1217
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