Abstract
Sulcal pits, the locally deepest points in sulci of the cerebral cortex, are found to be spatially highly consistent across human adult individuals. It is suggested that sulcal pits are genetically controlled and have close relationships with functional areas. To date, most imaging studies of sulcal pits are focused on adult brains, yet little is known about the spatial distribution and temporal development of sulcal pits in the first 2 years of life, the most dynamic period of postnatal brain development. Studying sulcal pits during this period would enrich our current limited understanding of the developmental trajectories of sulcal pits and provide insights into neurodevelopmental disorders associated with abnormal cortical foldings. In this paper, by using surface-based morphometry, for the first time, we systemically investigated the spatial distribution and temporal development of sulcal pits in major sulci from 73 healthy infants, each with longitudinal 3T MR scans at term birth, 1 year, and 2 years of age. Our results suggest that the consistency of spatial distribution of sulcal pits in major sulci across subjects has already existed at term birth and this spatial distribution pattern is relatively stable during cortex development in the first 2 years, despite that the cortex expands dramatically and the sulcal depth increases considerably.
| Original language | English |
|---|---|
| Title of host publication | 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| Pages | 1214-1217 |
| Number of pages | 4 |
| ISBN (Print) | 9781467319591 |
| Publication status | Published - 2014 Jul 29 |
| Externally published | Yes |
| Event | 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 - Beijing, China Duration: 2014 Apr 29 → 2014 May 2 |
Other
| Other | 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014 |
|---|---|
| Country | China |
| City | Beijing |
| Period | 14/4/29 → 14/5/2 |
Fingerprint
Keywords
- Cortical surface
- Infant
- Longitudinal development
- Sulcal depth
- Sulcal pits
ASJC Scopus subject areas
- Biomedical Engineering
- Radiology Nuclear Medicine and imaging
Cite this
Spatial distribution and longitudinal development of deep cortical sulcal landmarks in infants. / Meng, Yu; Li, Gang; Lin, Weili; Gilmore, John H.; Shen, Dinggang.
2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014. Institute of Electrical and Electronics Engineers Inc., 2014. p. 1214-1217 6868094.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Spatial distribution and longitudinal development of deep cortical sulcal landmarks in infants
AU - Meng, Yu
AU - Li, Gang
AU - Lin, Weili
AU - Gilmore, John H.
AU - Shen, Dinggang
PY - 2014/7/29
Y1 - 2014/7/29
N2 - Sulcal pits, the locally deepest points in sulci of the cerebral cortex, are found to be spatially highly consistent across human adult individuals. It is suggested that sulcal pits are genetically controlled and have close relationships with functional areas. To date, most imaging studies of sulcal pits are focused on adult brains, yet little is known about the spatial distribution and temporal development of sulcal pits in the first 2 years of life, the most dynamic period of postnatal brain development. Studying sulcal pits during this period would enrich our current limited understanding of the developmental trajectories of sulcal pits and provide insights into neurodevelopmental disorders associated with abnormal cortical foldings. In this paper, by using surface-based morphometry, for the first time, we systemically investigated the spatial distribution and temporal development of sulcal pits in major sulci from 73 healthy infants, each with longitudinal 3T MR scans at term birth, 1 year, and 2 years of age. Our results suggest that the consistency of spatial distribution of sulcal pits in major sulci across subjects has already existed at term birth and this spatial distribution pattern is relatively stable during cortex development in the first 2 years, despite that the cortex expands dramatically and the sulcal depth increases considerably.
AB - Sulcal pits, the locally deepest points in sulci of the cerebral cortex, are found to be spatially highly consistent across human adult individuals. It is suggested that sulcal pits are genetically controlled and have close relationships with functional areas. To date, most imaging studies of sulcal pits are focused on adult brains, yet little is known about the spatial distribution and temporal development of sulcal pits in the first 2 years of life, the most dynamic period of postnatal brain development. Studying sulcal pits during this period would enrich our current limited understanding of the developmental trajectories of sulcal pits and provide insights into neurodevelopmental disorders associated with abnormal cortical foldings. In this paper, by using surface-based morphometry, for the first time, we systemically investigated the spatial distribution and temporal development of sulcal pits in major sulci from 73 healthy infants, each with longitudinal 3T MR scans at term birth, 1 year, and 2 years of age. Our results suggest that the consistency of spatial distribution of sulcal pits in major sulci across subjects has already existed at term birth and this spatial distribution pattern is relatively stable during cortex development in the first 2 years, despite that the cortex expands dramatically and the sulcal depth increases considerably.
KW - Cortical surface
KW - Infant
KW - Longitudinal development
KW - Sulcal depth
KW - Sulcal pits
UR - http://www.scopus.com/inward/record.url?scp=84927923464&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84927923464&partnerID=8YFLogxK
M3 - Conference contribution
SN - 9781467319591
SP - 1214
EP - 1217
BT - 2014 IEEE 11th International Symposium on Biomedical Imaging, ISBI 2014
PB - Institute of Electrical and Electronics Engineers Inc.
ER -