Spatiotemporal maturation patterns of murine brian quantified by diffusion tensor MRI and deformation-based morphometry

Ragini Verma, Susumu Mori, Dinggang Shen, Paul Yarowsky, Jiangyang Zhang, Christos Davatzikos

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Highly heterogeneous spatiotemporal patterns of maturation of the murine brain during the first 80 postnatal days were examined by high-dimensional deformation-based morphometry applied to high-resolution diffusion tensor MRIs. The maturation profile revealed a sharp contrast between tissue anisotropy changes in the cortex and in major white-matter fibers. Radially oriented tissue anisotropy was measured during the first postnatal week in cortical regions, reflecting the underlying columnar organization of the cortex. Subsequently, tissue anisotropy reduced rapidly, potentially reflecting the growth of randomly oriented dendritic trees that reduce tissue coorientation. Distinct anisotropy patterns were also observed along layer I of the cortex and were attributed to thin fibers oriented parallel to the outer surface. Last, spatially complex patterns of maturation were measured in all major axonal pathways and in the hippocampus, caudate putamen, and cerebellum. This analysis provides a framework for quantifying normative maturation patterns against which phenotypes of mice of different genetic and environmental backgrounds can be contrasted.

Original languageEnglish
Pages (from-to)6978-6983
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume102
Issue number19
DOIs
Publication statusPublished - 2005 May 10
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • General

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