Spatiotemporal uptake characteristics of [18]F-2-fluoro-2-deoxy- d-glucose in a rat middle cerebral artery occlusion model

Hong Yuan, Jonathan E. Frank, Yonglong Hong, Hongyu An, Cihat Eldeniz, Jingxin Nie, Adomas Bunevicius, Dinggang Shen, Weili Lin

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE-: Alterations of cerebral glucose metabolism are well anticipated during cerebral ischemia. However, detailed spatiotemporal characteristics of disturbed cerebral glucose metabolism during acute ischemia remain largely elusive. This study aims to delineate spatiotemporal distributions of [18]F-2-fluoro-2-deoxy-D-glucose (FDG) uptake using positron emission tomography imaging, particularly at the peri-ischemic zone, and its correlation with tissue outcome. METHODS-: The intraluminal suture middle cerebral artery occlusion model was used to induce focal cerebral ischemia in rats (n=48). All animals underwent sequential MRI and FDG positron emission tomography imaging at different times (30-150 minutes) after middle cerebral artery occlusion. MR and positron emission tomography images were coregistered. FDG uptake in the peri-ischemic zone was assessed in relation to middle cerebral artery occlusion duration, cerebral blood flow, apparent diffusion coefficient, and 24-hour T2 lesions. RESULTS-: Elevated FDG uptake was consistently observed at the peri-ischemic zone surrounding the presumed ischemic core with low FDG uptake. Both the spatial volume and the uptake level of the hyper-uptake region were inversely correlated with the duration of middle cerebral artery occlusion. The hyper-uptake regions exhibited a mild reduction of cerebral blood flow (28.2±3.2%) and apparent diffusion coefficient (9.1±1.4%) when compared with that in the contralateral hemisphere. Colocalization analysis revealed that, with reperfusion, an average of 12.1±1.7% of the hyper-uptake volume was recruited into final infarction. CONCLUSIONS-: Elevated FDG uptake at the peri-ischemic zone is consistently observed during acute cerebral ischemia. The region with elevated FDG uptake likely reflects viable tissues that can be salvaged with reperfusion. Therefore, acute FDG positron emission tomography imaging might hold promise in the management of patients with acute stroke.

Original languageEnglish
Pages (from-to)2292-2299
Number of pages8
JournalStroke
Volume44
Issue number8
DOIs
Publication statusPublished - 2013 Aug 1
Externally publishedYes

Fingerprint

Middle Cerebral Artery Infarction
Deoxyglucose
Glucose
Positron-Emission Tomography
Cerebrovascular Circulation
Brain Ischemia
Reperfusion
Fluorodeoxyglucose F18
Infarction
Sutures
Ischemia
Stroke

Keywords

  • acute ischemic stroke
  • cerebral glucose metabolism
  • FDG PET

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing

Cite this

Spatiotemporal uptake characteristics of [18]F-2-fluoro-2-deoxy- d-glucose in a rat middle cerebral artery occlusion model. / Yuan, Hong; Frank, Jonathan E.; Hong, Yonglong; An, Hongyu; Eldeniz, Cihat; Nie, Jingxin; Bunevicius, Adomas; Shen, Dinggang; Lin, Weili.

In: Stroke, Vol. 44, No. 8, 01.08.2013, p. 2292-2299.

Research output: Contribution to journalArticle

Yuan, H, Frank, JE, Hong, Y, An, H, Eldeniz, C, Nie, J, Bunevicius, A, Shen, D & Lin, W 2013, 'Spatiotemporal uptake characteristics of [18]F-2-fluoro-2-deoxy- d-glucose in a rat middle cerebral artery occlusion model', Stroke, vol. 44, no. 8, pp. 2292-2299. https://doi.org/10.1161/STROKEAHA.113.000903
Yuan, Hong ; Frank, Jonathan E. ; Hong, Yonglong ; An, Hongyu ; Eldeniz, Cihat ; Nie, Jingxin ; Bunevicius, Adomas ; Shen, Dinggang ; Lin, Weili. / Spatiotemporal uptake characteristics of [18]F-2-fluoro-2-deoxy- d-glucose in a rat middle cerebral artery occlusion model. In: Stroke. 2013 ; Vol. 44, No. 8. pp. 2292-2299.
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AU - Yuan, Hong

AU - Frank, Jonathan E.

AU - Hong, Yonglong

AU - An, Hongyu

AU - Eldeniz, Cihat

AU - Nie, Jingxin

AU - Bunevicius, Adomas

AU - Shen, Dinggang

AU - Lin, Weili

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N2 - BACKGROUND AND PURPOSE-: Alterations of cerebral glucose metabolism are well anticipated during cerebral ischemia. However, detailed spatiotemporal characteristics of disturbed cerebral glucose metabolism during acute ischemia remain largely elusive. This study aims to delineate spatiotemporal distributions of [18]F-2-fluoro-2-deoxy-D-glucose (FDG) uptake using positron emission tomography imaging, particularly at the peri-ischemic zone, and its correlation with tissue outcome. METHODS-: The intraluminal suture middle cerebral artery occlusion model was used to induce focal cerebral ischemia in rats (n=48). All animals underwent sequential MRI and FDG positron emission tomography imaging at different times (30-150 minutes) after middle cerebral artery occlusion. MR and positron emission tomography images were coregistered. FDG uptake in the peri-ischemic zone was assessed in relation to middle cerebral artery occlusion duration, cerebral blood flow, apparent diffusion coefficient, and 24-hour T2 lesions. RESULTS-: Elevated FDG uptake was consistently observed at the peri-ischemic zone surrounding the presumed ischemic core with low FDG uptake. Both the spatial volume and the uptake level of the hyper-uptake region were inversely correlated with the duration of middle cerebral artery occlusion. The hyper-uptake regions exhibited a mild reduction of cerebral blood flow (28.2±3.2%) and apparent diffusion coefficient (9.1±1.4%) when compared with that in the contralateral hemisphere. Colocalization analysis revealed that, with reperfusion, an average of 12.1±1.7% of the hyper-uptake volume was recruited into final infarction. CONCLUSIONS-: Elevated FDG uptake at the peri-ischemic zone is consistently observed during acute cerebral ischemia. The region with elevated FDG uptake likely reflects viable tissues that can be salvaged with reperfusion. Therefore, acute FDG positron emission tomography imaging might hold promise in the management of patients with acute stroke.

AB - BACKGROUND AND PURPOSE-: Alterations of cerebral glucose metabolism are well anticipated during cerebral ischemia. However, detailed spatiotemporal characteristics of disturbed cerebral glucose metabolism during acute ischemia remain largely elusive. This study aims to delineate spatiotemporal distributions of [18]F-2-fluoro-2-deoxy-D-glucose (FDG) uptake using positron emission tomography imaging, particularly at the peri-ischemic zone, and its correlation with tissue outcome. METHODS-: The intraluminal suture middle cerebral artery occlusion model was used to induce focal cerebral ischemia in rats (n=48). All animals underwent sequential MRI and FDG positron emission tomography imaging at different times (30-150 minutes) after middle cerebral artery occlusion. MR and positron emission tomography images were coregistered. FDG uptake in the peri-ischemic zone was assessed in relation to middle cerebral artery occlusion duration, cerebral blood flow, apparent diffusion coefficient, and 24-hour T2 lesions. RESULTS-: Elevated FDG uptake was consistently observed at the peri-ischemic zone surrounding the presumed ischemic core with low FDG uptake. Both the spatial volume and the uptake level of the hyper-uptake region were inversely correlated with the duration of middle cerebral artery occlusion. The hyper-uptake regions exhibited a mild reduction of cerebral blood flow (28.2±3.2%) and apparent diffusion coefficient (9.1±1.4%) when compared with that in the contralateral hemisphere. Colocalization analysis revealed that, with reperfusion, an average of 12.1±1.7% of the hyper-uptake volume was recruited into final infarction. CONCLUSIONS-: Elevated FDG uptake at the peri-ischemic zone is consistently observed during acute cerebral ischemia. The region with elevated FDG uptake likely reflects viable tissues that can be salvaged with reperfusion. Therefore, acute FDG positron emission tomography imaging might hold promise in the management of patients with acute stroke.

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KW - cerebral glucose metabolism

KW - FDG PET

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