Sphingolipid identification and skin barrier recovery capacity of a milk sphingolipid-enriched fraction (MSEF) from buttermilk powder

K. Lee, S. Kim, A. Kim, H. J. Suh, K. B. Hong

Research output: Contribution to journalArticle

Abstract

Objective: In this study, we isolated the milk sphingolipid-enriched fraction (MSEF) of sweet buttermilk powder and conducted a clinical trial for evaluating its efficacy in skin barrier recovery. Methods: Milk sphingolipid-enriched fraction was isolated via solvent extraction of buttermilk powder, and further concentrated by removing the phospholipids and neutral lipids. A cream containing 1% MSEF was used during clinical trials to assess for water holding and skin barrier recovery capacities. Results: The main components of the MSEF were sphingomyelin, glucosylceramide and lactosylceramide, confirmed by TLC, HPLC, MS and NMR. The MSEF cream-treated group had a significantly higher (P < 0.05) water holding capacity, compared with the base cream (vehicle) group. Compared with that in the base cream group, transepidermal water loss (TEWL) recovery increased in the presence of the sphingolipid-containing MSEF cream (MSEF group), with a significant difference (P < 0.05) recorded on day 14. Conclusion: The MSEF cream contributed to improving the water holding capacity and skin barrier recovery of damaged skin. Therefore, sphingolipid-containing MSEF can be useful for strengthening or repairing skin barrier function.

Original languageEnglish
Pages (from-to)270-276
Number of pages7
JournalInternational Journal of Cosmetic Science
Volume42
Issue number3
DOIs
Publication statusPublished - 2020 Jun 1

Keywords

  • Glu-Cer
  • Lac-Cer
  • milk sphingolipid-enriched fraction
  • skin barrier function
  • sphingomyelin

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Ageing
  • Pharmaceutical Science
  • Drug Discovery
  • Dermatology
  • Colloid and Surface Chemistry

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