Sphingosine-1-phosphate receptors: Biology and therapeutic potential in kidney disease

S. K. Jo, A. Bajwa, A. S. Awad, K. R. Lynch, M. D. Okusa

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

The major sphingolipid metabolite, sphingosine-1-phosphate (S1P), has important biological functions. S1P is the ligand for a family of five G-protein-coupled receptors with distinct signaling pathways that regulate angiogenesis, vascular maturation, immunity, chemotaxis, and other important biological pathways. Recently, clinical trials have targeted S1P receptors (S1PRs) for autoimmune diseases and transplantation and have generated considerable interest in developing additional, more selective compounds. This review summarizes current knowledge on the biology of S1P and S1PRs that forms the basis for future drug development and the treatment of kidney disease.

Original languageEnglish
Pages (from-to)1220-1230
Number of pages11
JournalKidney International
Volume73
Issue number11
DOIs
Publication statusPublished - 2008 Jun

Keywords

  • Acute kidney injury
  • FTY720
  • Ischemia-reperfusion injury
  • S1P
  • SEW2871
  • Sphingolipid

ASJC Scopus subject areas

  • Nephrology

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