Sphingosine-1-phosphate receptors: Biology and therapeutic potential in kidney disease

S. K. Jo, A. Bajwa, A. S. Awad, K. R. Lynch, M. D. Okusa

    Research output: Contribution to journalReview articlepeer-review

    65 Citations (Scopus)

    Abstract

    The major sphingolipid metabolite, sphingosine-1-phosphate (S1P), has important biological functions. S1P is the ligand for a family of five G-protein-coupled receptors with distinct signaling pathways that regulate angiogenesis, vascular maturation, immunity, chemotaxis, and other important biological pathways. Recently, clinical trials have targeted S1P receptors (S1PRs) for autoimmune diseases and transplantation and have generated considerable interest in developing additional, more selective compounds. This review summarizes current knowledge on the biology of S1P and S1PRs that forms the basis for future drug development and the treatment of kidney disease.

    Original languageEnglish
    Pages (from-to)1220-1230
    Number of pages11
    JournalKidney International
    Volume73
    Issue number11
    DOIs
    Publication statusPublished - 2008 Jun

    Keywords

    • Acute kidney injury
    • FTY720
    • Ischemia-reperfusion injury
    • S1P
    • SEW2871
    • Sphingolipid

    ASJC Scopus subject areas

    • Nephrology

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