Sphingosine kinase inhibitor suppresses dendritic cell migration by regulating chemokine receptor expression and impairing p38 mitogen-activated protein kinase

In Duk Jung, Jun Sik Lee, Yong Joo Kim, Young Il Jeong, Chang Min Lee, Min Goo Lee, Soon Choel Ahn, Yeong Min Park

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The migration of dendritic cells (DCs) to secondary lymphoid organs plays a crucial role in the initiation of adaptive immune responses. Although lipopolysaccharide enhances chemokine receptor 7 (CCR7) expression on DCs, the second signal for the migration of DCs toward the chemokine CCL19 remains unknown. In this study, we show that sphingosine kinase inhibitor (SKI) inhibits the migration of DCs toward CCL19 through the down-regulation of CCR7. Inhibition of p38 mitogen-activated protein kinase (MAPK) activation by SKI may be responsible for the SKI-mediated effects on the regulation of chemokine receptor expression. Impairment of DC migration by the inhibition of p38 MAPK and down-regulation of CCR7 expression may contribute to the protective effects of SKI in DC-related disorders. These results suggest that sphingosine kinase-mediated signalling plays a role in the innate and adaptive immune responses by altering DC migration.

Original languageEnglish
Pages (from-to)533-544
Number of pages12
JournalImmunology
Volume121
Issue number4
DOIs
Publication statusPublished - 2007 Aug

Keywords

  • Chemokine receptor
  • Dendritic cell
  • Migration
  • Sphingosine kinase

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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