Spontaneous bone regeneration in surgically induced bone defects in young rabbits

Hae Ryong Song, Ajay Puri, Jeong Hee Lee, Hyung Bin Park, Do Kyung Ra, Gon Sup Kim, Seong Chan Yeon

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Defects of the femoral shaft (15%, 20%, 25%, and 30% of the femoral length) with intact periosteum were made in young rabbits to investigate differences in union time. The mean union time was 7.3, 7.1, 7.4, and 7.0 weeks, respectively and there was no significant difference (P>0.05) between the groups. The mean healing indices were 6.7, 4.6, 3.9, and 3.1 weeks/cm, respectively and these were significantly different (P < 0.05) between the 15% bone defect group and the other bone defect groups. These results suggested that union time was not affected by the amount of bone defect. Femoral lengthening of 20% was performed to compare the quality of callus with those of the femoral defect of 20%. The mean healing indices of defect and lengthening were 4.6 and 5.7, respectively and the difference was significant (P = 0.004). The callus stiffness of femoral defect was higher (P = 0.02) than that after femoral lengthening whereas the bone mineral density of the callus showed no significant difference (P = 0.37) between two groups. The method of filling bone defect with callus generated from the intact periosteum may be a new therapeutic option for the reconstruction of large bone defects in children when other treatments are not available.

Original languageEnglish
Pages (from-to)343-349
Number of pages7
JournalJournal of Pediatric Orthopaedics Part B
Volume11
Issue number4
Publication statusPublished - 2002 Oct 1
Externally publishedYes

Fingerprint

Bone Regeneration
Thigh
Bony Callus
Rabbits
Bone and Bones
Periosteum
Bone Density
Therapeutics

Keywords

  • Bone defect
  • Bone lengthening
  • Callus analysis
  • Rabbit

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Song, H. R., Puri, A., Lee, J. H., Park, H. B., Ra, D. K., Kim, G. S., & Yeon, S. C. (2002). Spontaneous bone regeneration in surgically induced bone defects in young rabbits. Journal of Pediatric Orthopaedics Part B, 11(4), 343-349.

Spontaneous bone regeneration in surgically induced bone defects in young rabbits. / Song, Hae Ryong; Puri, Ajay; Lee, Jeong Hee; Park, Hyung Bin; Ra, Do Kyung; Kim, Gon Sup; Yeon, Seong Chan.

In: Journal of Pediatric Orthopaedics Part B, Vol. 11, No. 4, 01.10.2002, p. 343-349.

Research output: Contribution to journalArticle

Song, HR, Puri, A, Lee, JH, Park, HB, Ra, DK, Kim, GS & Yeon, SC 2002, 'Spontaneous bone regeneration in surgically induced bone defects in young rabbits', Journal of Pediatric Orthopaedics Part B, vol. 11, no. 4, pp. 343-349.
Song, Hae Ryong ; Puri, Ajay ; Lee, Jeong Hee ; Park, Hyung Bin ; Ra, Do Kyung ; Kim, Gon Sup ; Yeon, Seong Chan. / Spontaneous bone regeneration in surgically induced bone defects in young rabbits. In: Journal of Pediatric Orthopaedics Part B. 2002 ; Vol. 11, No. 4. pp. 343-349.
@article{c5e2515a2fa843dd9d84066e0ca63760,
title = "Spontaneous bone regeneration in surgically induced bone defects in young rabbits",
abstract = "Defects of the femoral shaft (15{\%}, 20{\%}, 25{\%}, and 30{\%} of the femoral length) with intact periosteum were made in young rabbits to investigate differences in union time. The mean union time was 7.3, 7.1, 7.4, and 7.0 weeks, respectively and there was no significant difference (P>0.05) between the groups. The mean healing indices were 6.7, 4.6, 3.9, and 3.1 weeks/cm, respectively and these were significantly different (P < 0.05) between the 15{\%} bone defect group and the other bone defect groups. These results suggested that union time was not affected by the amount of bone defect. Femoral lengthening of 20{\%} was performed to compare the quality of callus with those of the femoral defect of 20{\%}. The mean healing indices of defect and lengthening were 4.6 and 5.7, respectively and the difference was significant (P = 0.004). The callus stiffness of femoral defect was higher (P = 0.02) than that after femoral lengthening whereas the bone mineral density of the callus showed no significant difference (P = 0.37) between two groups. The method of filling bone defect with callus generated from the intact periosteum may be a new therapeutic option for the reconstruction of large bone defects in children when other treatments are not available.",
keywords = "Bone defect, Bone lengthening, Callus analysis, Rabbit",
author = "Song, {Hae Ryong} and Ajay Puri and Lee, {Jeong Hee} and Park, {Hyung Bin} and Ra, {Do Kyung} and Kim, {Gon Sup} and Yeon, {Seong Chan}",
year = "2002",
month = "10",
day = "1",
language = "English",
volume = "11",
pages = "343--349",
journal = "Journal of Pediatric Orthopaedics Part B",
issn = "1060-152X",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Spontaneous bone regeneration in surgically induced bone defects in young rabbits

AU - Song, Hae Ryong

AU - Puri, Ajay

AU - Lee, Jeong Hee

AU - Park, Hyung Bin

AU - Ra, Do Kyung

AU - Kim, Gon Sup

AU - Yeon, Seong Chan

PY - 2002/10/1

Y1 - 2002/10/1

N2 - Defects of the femoral shaft (15%, 20%, 25%, and 30% of the femoral length) with intact periosteum were made in young rabbits to investigate differences in union time. The mean union time was 7.3, 7.1, 7.4, and 7.0 weeks, respectively and there was no significant difference (P>0.05) between the groups. The mean healing indices were 6.7, 4.6, 3.9, and 3.1 weeks/cm, respectively and these were significantly different (P < 0.05) between the 15% bone defect group and the other bone defect groups. These results suggested that union time was not affected by the amount of bone defect. Femoral lengthening of 20% was performed to compare the quality of callus with those of the femoral defect of 20%. The mean healing indices of defect and lengthening were 4.6 and 5.7, respectively and the difference was significant (P = 0.004). The callus stiffness of femoral defect was higher (P = 0.02) than that after femoral lengthening whereas the bone mineral density of the callus showed no significant difference (P = 0.37) between two groups. The method of filling bone defect with callus generated from the intact periosteum may be a new therapeutic option for the reconstruction of large bone defects in children when other treatments are not available.

AB - Defects of the femoral shaft (15%, 20%, 25%, and 30% of the femoral length) with intact periosteum were made in young rabbits to investigate differences in union time. The mean union time was 7.3, 7.1, 7.4, and 7.0 weeks, respectively and there was no significant difference (P>0.05) between the groups. The mean healing indices were 6.7, 4.6, 3.9, and 3.1 weeks/cm, respectively and these were significantly different (P < 0.05) between the 15% bone defect group and the other bone defect groups. These results suggested that union time was not affected by the amount of bone defect. Femoral lengthening of 20% was performed to compare the quality of callus with those of the femoral defect of 20%. The mean healing indices of defect and lengthening were 4.6 and 5.7, respectively and the difference was significant (P = 0.004). The callus stiffness of femoral defect was higher (P = 0.02) than that after femoral lengthening whereas the bone mineral density of the callus showed no significant difference (P = 0.37) between two groups. The method of filling bone defect with callus generated from the intact periosteum may be a new therapeutic option for the reconstruction of large bone defects in children when other treatments are not available.

KW - Bone defect

KW - Bone lengthening

KW - Callus analysis

KW - Rabbit

UR - http://www.scopus.com/inward/record.url?scp=0036786079&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036786079&partnerID=8YFLogxK

M3 - Article

VL - 11

SP - 343

EP - 349

JO - Journal of Pediatric Orthopaedics Part B

JF - Journal of Pediatric Orthopaedics Part B

SN - 1060-152X

IS - 4

ER -