Spontaneous low-frequency cerebral hemodynamics oscillations in restless legs syndrome with periodic limb movements during sleep: A near-infrared spectroscopy study

Jung Ick Byuna, Ki Young Jung, Gwan Taek Lee, Choong Ki Kim, Beop Min Kimd

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background and PurposezzPeriodic limb movements (PLM) during sleep (PLMS) are asso- ciated with cortical and cardiovascular activation. Changes in cerebral hemodynamics caused by cortical activity can be measured using near-infrared spectroscopy (NIRS). We investigated oscillatory components of cerebral hemodynamics during PLM and different sleep stages in restless legs syndrome (RLS) patients with PLMS. Methods Four female RLS patients with PLMS, and four age- and sex-matched normal controls were included. PLM and sleep stages were scored using polysomnography, while the spontaneous cerebral hemodynamics was measured by NIRS. The phase and amplitude of the cerebral oxyhemoglobin concentration [HbO] and the deoxyhemoglobin concentration [Hb] low-frequency oscillations (LFOs) were evaluated during each sleep stage [waking, light sleep (LS; stages N1 and N2), slow-wave sleep (stage N3), and rapid eye movement (REM) sleep]. In RLS patients with PLMS, the cerebral hemodynamics during LS was divided into LS with and without PLM. Results The cerebral hemodynamics activity varied among the different sleep stages. There were changes in phase differences between [HbO] and [Hb] LFOs during the different sleep stages in the normal controls but not in the RLS patients with PLMS. The [HbO] and [Hb] LFO amplitudes were higher in the patient group than in controls during both LS with PLM and REM sleep. Conclusions The present study has demonstrated the presence of cerebral hemodynamics disturbances in RLS patients with PLMS, which may contribute to an increased risk of cerebro- vascular events.

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalJournal of Clinical Neurology (Korea)
Volume12
Issue number1
DOIs
Publication statusPublished - 2016 Jan

Keywords

  • Hemodynamics
  • Low-frequency oscillations
  • Near-infrared spectroscopy
  • Periodic limb movement during sleep
  • Restless legs syndrome

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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