Abstract
Compromised T-cell immunity persists for up to 1 year after autologous stem cell transplantation (ASCT), and patients treated with ASCT are more likely to develop atypical lymphoid hyperplasia that mimics tumor recurrence. Here, we present a case of cervical lymphadenitis due to cytomegalovirus (CMV) reactivation in a patient who had undergone ASCT for Burkitt lymphoma, which mimicked tumor recurrence on computed tomography and positron emission tomography-computed tomography 6 months after ASCT. This lesion was confined to the regional lymph nodes and was not accompanied by signs of systemic involvement, such as fever, splenomegaly, an elevated C-reactive protein level, or viremia. The localized CMV lymphadenitis resolved spontaneously without treatment after 6 months (12 months after ASCT) and the elevated CMV immunoglobulin-M titer normalized 6 months after resolution. Our experience with this case suggests that cautious follow-up without anti-CMV treatment should be considered in cases of post-ASCT localized CMV lymphadenitis without systemic involvement in patients with complete engraftment.
| Original language | English |
|---|---|
| Pages (from-to) | 676-680 |
| Number of pages | 5 |
| Journal | Transplant Infectious Disease |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Atypical lymphoid hyperplasia
- Autologous stem cell transplantation
- CMV
- Cytomegalovirus lymphadenitis
ASJC Scopus subject areas
- Transplantation
- Infectious Diseases
- Medicine(all)
Cite this
Spontaneous resolution of post-transplant localized cytomegalovirus lymphadenitis mimicking tumor recurrence. / Kang, K. W.; Lee, Ju-Han; Choi, J. S.; Lee, Se Ryeon; Park, Yong; Kim, Byung Soo; Kim, I.
In: Transplant Infectious Disease, Vol. 16, No. 4, 2014, p. 676-680.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Spontaneous resolution of post-transplant localized cytomegalovirus lymphadenitis mimicking tumor recurrence
AU - Kang, K. W.
AU - Lee, Ju-Han
AU - Choi, J. S.
AU - Lee, Se Ryeon
AU - Park, Yong
AU - Kim, Byung Soo
AU - Kim, I.
PY - 2014
Y1 - 2014
N2 - Compromised T-cell immunity persists for up to 1 year after autologous stem cell transplantation (ASCT), and patients treated with ASCT are more likely to develop atypical lymphoid hyperplasia that mimics tumor recurrence. Here, we present a case of cervical lymphadenitis due to cytomegalovirus (CMV) reactivation in a patient who had undergone ASCT for Burkitt lymphoma, which mimicked tumor recurrence on computed tomography and positron emission tomography-computed tomography 6 months after ASCT. This lesion was confined to the regional lymph nodes and was not accompanied by signs of systemic involvement, such as fever, splenomegaly, an elevated C-reactive protein level, or viremia. The localized CMV lymphadenitis resolved spontaneously without treatment after 6 months (12 months after ASCT) and the elevated CMV immunoglobulin-M titer normalized 6 months after resolution. Our experience with this case suggests that cautious follow-up without anti-CMV treatment should be considered in cases of post-ASCT localized CMV lymphadenitis without systemic involvement in patients with complete engraftment.
AB - Compromised T-cell immunity persists for up to 1 year after autologous stem cell transplantation (ASCT), and patients treated with ASCT are more likely to develop atypical lymphoid hyperplasia that mimics tumor recurrence. Here, we present a case of cervical lymphadenitis due to cytomegalovirus (CMV) reactivation in a patient who had undergone ASCT for Burkitt lymphoma, which mimicked tumor recurrence on computed tomography and positron emission tomography-computed tomography 6 months after ASCT. This lesion was confined to the regional lymph nodes and was not accompanied by signs of systemic involvement, such as fever, splenomegaly, an elevated C-reactive protein level, or viremia. The localized CMV lymphadenitis resolved spontaneously without treatment after 6 months (12 months after ASCT) and the elevated CMV immunoglobulin-M titer normalized 6 months after resolution. Our experience with this case suggests that cautious follow-up without anti-CMV treatment should be considered in cases of post-ASCT localized CMV lymphadenitis without systemic involvement in patients with complete engraftment.
KW - Atypical lymphoid hyperplasia
KW - Autologous stem cell transplantation
KW - CMV
KW - Cytomegalovirus lymphadenitis
UR - http://www.scopus.com/inward/record.url?scp=84905578588&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905578588&partnerID=8YFLogxK
U2 - 10.1111/tid.12254
DO - 10.1111/tid.12254
M3 - Article
C2 - 24965019
AN - SCOPUS:84905578588
VL - 16
SP - 676
EP - 680
JO - Transplant Infectious Disease
JF - Transplant Infectious Disease
SN - 1398-2273
IS - 4
ER -