Abstract
Compromised T-cell immunity persists for up to 1 year after autologous stem cell transplantation (ASCT), and patients treated with ASCT are more likely to develop atypical lymphoid hyperplasia that mimics tumor recurrence. Here, we present a case of cervical lymphadenitis due to cytomegalovirus (CMV) reactivation in a patient who had undergone ASCT for Burkitt lymphoma, which mimicked tumor recurrence on computed tomography and positron emission tomography-computed tomography 6 months after ASCT. This lesion was confined to the regional lymph nodes and was not accompanied by signs of systemic involvement, such as fever, splenomegaly, an elevated C-reactive protein level, or viremia. The localized CMV lymphadenitis resolved spontaneously without treatment after 6 months (12 months after ASCT) and the elevated CMV immunoglobulin-M titer normalized 6 months after resolution. Our experience with this case suggests that cautious follow-up without anti-CMV treatment should be considered in cases of post-ASCT localized CMV lymphadenitis without systemic involvement in patients with complete engraftment.
Original language | English |
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Pages (from-to) | 676-680 |
Number of pages | 5 |
Journal | Transplant Infectious Disease |
Volume | 16 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2014 Aug |
Keywords
- Atypical lymphoid hyperplasia
- Autologous stem cell transplantation
- CMV
- Cytomegalovirus lymphadenitis
ASJC Scopus subject areas
- Infectious Diseases
- Transplantation