Squeezing hydrogels for controlled oral drug delivery

Anna Gutowska, Jong Seok Bark, Ick Chan Kwon, You Han Bae, Younsik Cha, Sung Wan Kim

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

A new delivery device based on a novel, squeezing hydrogel concept, utilizing specific swelling-deswelling characteristics of temperature-, temperature/pH- and pH -sensitive hydrogels is described. These hydrogels have been designed to exhibit controlled swelling-deswelling kinetics, hence, a variety of release profiles may be generated including: delayed, zero-order or on-off release profiles. A temperature sensitive NiPAAm/AAc hydrogel demonstrated a squeezing controlled 'on-off' release profile in response to a temperature change between 35°and 40°C with the 'on' phase at higher temperature. Drug release profiles from a pH/T sensitive NiPAAm/BMA/DEAEMA hydrogel were strongly affected by a pH change at 37°C. The gel demonstrated a minimal delayed release at pH 2.0 and a zero-order release at pH 7.4 controlled by mechanical squeezing mechanism that was determined by the gel deswelling kinetics. A delayed and a zero-order release profiles were also obtained for a pH sensitive cationic hydrogel in response to a pH change from pH 2.0 to 7.4. For all studied systems, it was concluded that a gel composition and an applied stimuli (T, pH, pH/T), determined the gel swelling/deswelling kinetics and the release profiles.

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalJournal of Controlled Release
Volume48
Issue number2-3
DOIs
Publication statusPublished - 1997 Oct 13
Externally publishedYes

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Keywords

  • Controlled oral drug delivery
  • Drug delivery device
  • pH-Sensitive hydrogels
  • Swelling/deswelling kinetics
  • Temperature-sensitive hydrogels

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Gutowska, A., Bark, J. S., Kwon, I. C., Bae, Y. H., Cha, Y., & Kim, S. W. (1997). Squeezing hydrogels for controlled oral drug delivery. Journal of Controlled Release, 48(2-3), 141-148. https://doi.org/10.1016/S0168-3659(97)00041-2