Stabilin-2 acts as an engulfment receptor for the phosphatidylserine-dependent clearance of primary necrotic cells

Shilpa D'Souza, Seung Yoon Park, In San Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Phosphatidylserine (PS) exposed by necrotic cells serves as an engulfment signal for their effective clearance. However, the molecular mechanism responsible for the PS-dependent clearance of necrotic cells remains to be investigated. Here, we show that stabilin-2 acts as a receptor for necrotic cell clearance. Stabilin-2-mediated necrotic cell engulfment occurred in a PS-dependent manner. EGF-like domain repeat (a PS-recognition domain of stabilin-2) bound to necrotic cells and inhibited the stabilin-2-mediated engulfment. However, primary necrotic cells did not induce the anti-inflammatory effect in stabilin-2-expressing cells. These findings facilitate the elucidation of the molecular mechanisms responsible for the PS-dependent clearance of necrotic cells.

Original languageEnglish
Pages (from-to)412-417
Number of pages6
JournalBiochemical and biophysical research communications
Volume432
Issue number3
DOIs
Publication statusPublished - 2013 Mar 15
Externally publishedYes

Keywords

  • Necrotic cells
  • Phagocytosis
  • Phosphatidylserine
  • Stabilin-2

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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